Results 101 to 110 of about 56,119 (295)

Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast [PDF]

, 2012
The inheritance of the histone H3 variant CENP-A in nucleosomes at centromeres following DNA replication is mediated by an epigenetic mechanism. To understand the process of epigenetic inheritance, or propagation of histones and histone variants, as ...
Allshire, Robin C, Berger, Harald, Carr, Antony M, Dunne, Paul D, Endesfelder, Ulrike, Heilemann, Mike, Klenerman, David, Lando, David, Laue, Ernest D, McColl, James, Sauer, Markus, Subramanian, Lakxmi   +11 more
core   +2 more sources

Computational systems biology approaches to cellular aging—Integrating network maps and dynamical models

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cellular aging is a multifaceted complex process. Many genes and factors have been identified that regulate cellular aging. However, how these genes and factors interact with one another and how these interactions drive the aging processes in single cells remain largely unclear.
Hetian Su, Nan Hao
wiley   +1 more source

Can Unicellular Organisms Sequester a Germline? The Yeast‐Germline Hypothesis

BioEssays, Volume 47, Issue 6, June 2025.
Asymmetrical inheritance of template‐DNA and copy‐DNA strands during mitosis can reduce the number of mutant cells. This requires that cells continuing to divide inherit the “immortal” template‐DNA, while their daughter cells become quiescent and inherit copy‐DNA strands.
Bhavya Sree Vadlamudi, Duur K. Aanen
wiley   +1 more source

Silencing Motifs in the Clr2 Protein from Fission Yeast, Schizosaccharomyces pombe

PLoS ONE, 2014
The fission yeast, Schizosaccharomyces pombe, is a well-established model for heterochromatin formation, but the exact sequence of events for initiation remains to be elucidated. The essential factors involved include RNA transcribed from repeated sequences together with the methyltransferase Clr4. In addition, histone deacetylases, like Clr3, found in
Steinhauf, Daniel, Rodriguez, Alejandro, Vlachakis, Dimitrios, Virgo, Gordon, Maksimov, Vladimir, Kristell, Carolina, Olsson, Ida, Linder, Tomas, Kossida, Sophia, Bongcam-Rudloff, Erik, Bjerling, Pernilla   +10 more
openaire   +6 more sources

PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast. [PDF]

PLoS Genetics, 2017
PCNA ubiquitylation on lysine 164 is required for DNA damage tolerance. In many organisms PCNA is also ubiquitylated in unchallenged S phase but the significance of this has not been established.
Yasukazu Daigaku, Thomas J Etheridge, Yuka Nakazawa, Mayumi Nakayama, Adam T Watson, Izumi Miyabe, Tomoo Ogi, Mark A Osborne, Antony M Carr   +8 more
doaj   +1 more source

Excluded volume effect enhances the homology pairing of model chromosomes [PDF]

arXiv, 2015
To investigate the structural dynamics of the homology pairing of polymers, we mod- eled the scenario of homologous chromosome pairings during meiosis in Schizosaccharomyces pombe, one of the simplest model organisms of eukaryotes. We consider a simple model consist- ing of pairs of homologous polymers with the same structures that are confined in a ...
arxiv  

DNA repair, DNA replication and human disorders: A personal journey [PDF]

, 2012
I was born in 1946 and grew up in the industrial north-west of England close to the city of Manchester. My parents were German- Jewish refugees, who left Germany fairly early, in 1933.
Alan R. Lehmann, Barnes, Barnes, Bienko, Bohr, Broughton, Burk, Carr, Cleaver, Cordonnier, Daigaku, Domon, Edmunds, Fenech, Fousteri, Gebara, Griffiths, Henderson, Hirano, Hoege, Johnson, Kannouche, Kannouche, Kannouche, Karras, Kleijer, Lee, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lett, Ley, Masutani, Mayne, McDonald, McGrath, Mellon, Murray, Murray, Nduka, Ogi, Okazaki, Palecek, Phipps, Regan, Rupp, Rupp, Saitoh, Savitsky, Schaeffer, Schmickel, Sergeant, Setlow, Stefanini, Strunnikov, Taylor, Taylor, Taylor, Teo, Tissier, Tsukada, van Duin, Venema, Weber   +75 more
core   +1 more source

Sugar‐sensing swodkoreceptors and swodkocrine signaling

Animal Models and Experimental Medicine, Volume 8, Issue 5, Page 944-961, May 2025.
Sugar‐sensing swodkoreceptors that trigger swodkocrine signaling. Abstract Sugars are one of the major metabolites and are essential for nucleic acid synthesis and energy production. In addition, sugars can act as signaling molecules. To study sugar signaling at the systemic level, there is an urgent need to systematically identify sugar‐sensing ...
Savani Anbalagan
wiley   +1 more source

Isolation and Characterization of Various Complexes of the Minichromosome Maintenance Proteins of Schizosaccharomyces pombe [PDF]

Journal of Biological Chemistry, 2000
Minichromosome maintenance (Mcm) proteins 2-7 are highly conserved in eukaryotes and play an essential role in DNA replication. Here, we describe the reconstitution of the various complexes of the Mcm proteins of Schizosaccharomyces pombe using the baculovirus expression system.
Joon-Kyu Lee, Jerard Hurwitz
openaire   +3 more sources

Information profiles for DNA pattern discovery [PDF]

arXiv, 2014
Finite-context modeling is a powerful tool for compressing and hence for representing DNA sequences. We describe an algorithm to detect genomic regularities, within a blind discovery strategy. The algorithm uses information profiles built using suitable combinations of finite-context models.
arxiv