Results 131 to 140 of about 5,952,242 (284)

A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

open access: yesAdvanced Science, EarlyView.
An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li   +15 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

open access: yesAdvanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang   +16 more
wiley   +1 more source

Economics of scholarly communication in transition

open access: yesFirst Monday, 2013
Academic library budgets are the primary source of revenue for scholarly journal publishing. There is more than enough money in the budgets of academic libraries to fund a fully open access scholarly journal publishing system. Seeking efficiencies, such as a reasonable average cost per article, will be key to a successful transition.
openaire   +2 more sources

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren   +11 more
wiley   +1 more source

Platformization of Scholarly Communication: Academic Social Networking Sites as New Infrastructures and Organizations

open access: yesEmerging Media
Digital platforms have established new arenas for scholarly communication. The two Academic Social Networking Sites (ASNSs) ResearchGate and Academia.edu provide infrastructures that fit into the basic structure of the predigital scholarly communication ...
Stella Köchling
doaj   +1 more source

Faculty Learning Communities are a Positive Way for Libraries to Engage Academic Staff in Scholarly Communication [PDF]

open access: yes, 2015
The stakes and politics of research and scholarship are different depending on discipline, department, and institution, and as such, increasing awareness of scholarly communication is fraught with difficulty.
Bazeley, Jennifer W, Waller, Jen
core  

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

open access: yesAdvanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu   +13 more
wiley   +1 more source

Teaching Communities of Faculty About Scholarly Communication [PDF]

open access: yes, 2014
This article by Jennifer Bazeley and Jen Waller originally appeared on the LSE Impact of Social Sciences blog as “Faculty Learning Communities are a positive way for libraries to engage academic staff in scholarly communication” and was re-posted under ...
Bazeley, Jennifer W, Waller, Jen
core  

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