Results 41 to 50 of about 989,611 (332)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Design Methodology for Exploring and Communicating System Values and Assumptions

Journal of the Text Encoding Initiative, 2014
This paper attempts to make two contributions to discussions related to TEI: (1) an analysis of how tools used for working with TEI documents encourage certain values and make certain assumptions about the work of textual editing and (2) a report on a ...
Daniel Carter
doaj   +1 more source

Writing as life performed [PDF]

, 2014
In this chapter I explore the interrelatedness of practice, rehearsal, and performance and their applicability in the domain of “life.” These relationships are complicated when, in reference to Adorno’s Minima Moralia, the content of critical-essayistic ...
Parker Dixon, Martin J.C.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Modeling genetic networks. Gustave Roud's œuvre, from diary to poetry collections

Umanistica Digitale, 2019
This paper pursues the analysis, modelling and representation of the relationships between the different entities concerned by genetic criticism (documents and publications), in the context of a scholarly digital edition.Our cases study are taken from ...
Alessio Christen, Elena Spadini
doaj   +1 more source

Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals

, 2018
I. About the Recommendations A. Purpose of the Recommendations B. Who Should Use the Recommendations? C. History of the Recommendations II. Roles and Responsibilities of Authors, Contributors, Reviewers, Editors, Publishers, andOwners A.
SobRe LA RecomendAcIoneS
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Visualising the Catalogues of Digital Editions

Journal of Electronic Publishing
This article provides a data-driven overview of the developments in the field of digital scholarly editing. It surveys and evaluates the available data source on digital scholarly editions and provides longitudinal analysis of changes in number of ...
Bridgette Wessels, James O'Sullivan, Michael Kurzmeier, Mike Pidd, Orla Murphy   +4 more
doaj   +2 more sources

Opening the book: data models and distractions in digital scholarly editing

International Journal of Digital Humanities, 2019
This article argues that editors of scholarly digital editions should not be distracted by underlying technological concerns except when these concerns affect the editorial tasks at hand.
J. Cummings
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source