Results 101 to 110 of about 33,049,667 (246)

The Promise of Evidence-Based Policymaking: Report of the Commission on Evidence-Based Policymaking, Appendices E-H

, 2017
Final report appendices E-H of the Commission on Evidence-Based Policymaking (CEP) containing the information gathered through the commission's survey of federal offices, public meeting materials and presentations, public input-hearing testimony and ...
United States. Commission on Evidence-Based Policymaking
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Sustaining mental health and wellbeing programmes in schools: recommendations from an online roundtable

Frontiers in Education
Despite recent investments in school-based mental health and wellbeing promotion in England, the sustainability of mental health interventions remains a substantial challenge.
Anna March, Anna March, Emily Stapley, Daniel Hayes, Darren Moore, Jessica Deighton   +5 more
doaj   +1 more source

The Promise of Evidence-Based Policymaking: Appendices E-H

, 2017
Supplementary appendices that support the final report of the Commission on Evidence-Based Policymaking including ..
United States. Commission on Evidence-Based Policymaking.
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

1909 School of Marine Engineering (poster) [PDF]

, 2014
A poster image of showing the the School of Marine Engineering at the Naval Academy in Annapolis in 1909, and the USS Connecticut, flagship of the Great White ...

core   +1 more source

Exploring the Impact of School-Based Physical and Perceived Environments on Students’ Physical Activity During Recess: A Case Study of Four Schools in Xi’an, China

Buildings
In the context of high academic pressure and inadequate physical activity (PA) among adolescents, it is important to study how the physical environment and students’ perceptions affect their physical activity during school recess.
Qing Wang, Yan Wang, Lan Zhou, Yong Nan
doaj   +1 more source

The Promise of Evidence-Based Policymaking

, 2017
Report of the Commission on Evidence-Based Policymaking providing a final report of their findings that..
United States. Commission on Evidence-Based Policymaking.
core