Results 81 to 90 of about 33,049,667 (246)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Effect of physical activity on anthropometric and physiological parameters in preschool and school-aged children: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Public Health
BackgroundEarly childhood is an essential phase characterized by physical, social, and cognitive development. This developmental stage lays the foundation for establishing lifelong health behavior patterns that can resonate into adolescence and adulthood.
Nina Wang, Qinglei Wang, Mengyan Wang, Mohd Nazri Bin Abdul Rahman   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Mental health knowledge, stigma towards mental illness, and help-seeking among adolescents in secondary schools in Kampala, Uganda

Cambridge Prisms: Global Mental Health
Mental health disorders are prevalent among adolescents and evidence suggests that stigma, poor mental health literacy (MHL) and access are key barriers to help-seeking for mental health difficulties in adolescence and throughout life.
Zenah Nantumbwe, Rosco Kasujja, Georg Schomerus   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Multicomponent intervention for schoolchildren with asthma: Pilot cluster randomized controlled trial

Journal of Allergy and Clinical Immunology: Global
Background: Physical activity (PA) is an important factor in asthma management. However, studies report low PA in children with asthma living in underserved communities.
Marina Reznik, MD, MS, Florinda Islamovic, MD, Jill S. Halterman, MD, MPH, Cheng-Shiun Leu, PhD, Jiaqing Zhang, PhD, Philip O. Ozuah, MD, PhD   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

School-based supervised therapy programs to improve asthma outcomes: current perspectives

Journal of Asthma and Allergy, 2018
Guadalupe Salazar, Geeta Tarwala, Marina Reznik Division of Academic General Pediatrics, Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA Background: Asthma is one of the most common chronic diseases of ...
Salazar G, Tarwala G, Reznik M
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Del Monte Pre Flight School History [video]

, 2015
The Naval Postgraduate School campus, once home of the world-renowned Hotel Del Monte, is one of the most historic sites in the American West. This set of short videos explains the hotel's significance and its transformation into today's NPS.The Navy's ...
Naval Postgraduate School, Sanders, John
core   +2 more sources