Results 91 to 100 of about 9,442,852 (336)

The teacher-librarian as school principal: A natural progression [PDF]

, 1992
Focuses on the roles and responsibilities of teacher-librarian in administration. How teacher-librarians are no different from others in education or librarianship who accept challenges of greater responsibility; Five major areas of responsibilities of ...
Haycock, Ken
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Análise do clima organizacional do curso de psicologia de uma universidade comunitária

Psicologia Escolar e Educacional
O estudo do clima organizacional é uma importante ferramenta para diagnóstico e compreensão das organizações, fornecendo subsídios para melhorias futuras.
Keli Cristina de Lara Campos
doaj  

Tracing Food Education for Sustainable Development in iPOPY countries. Recommendations for learning about sustainability and organic food within educational contexts. [PDF]

, 2010
Food Education for Sustainable Development (FESD) is evolving into a topical entity included in education in European countries due to the growing focus on environmental and health problems, which cause a ‘sustainability deficit’ within the food system.
Mikkola, Minna, Roos, Gun
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Organization of contryside school: conceptions and expectations of teachers

Revista Brasileira de Educação do Campo, 2019
This paper is the result of a research project which aimed at analyzing the conceptions and expectations of teachers regarding the organization of countryside school.
Lindalva Maria Novaes Garske , Lucimara Afonso Castilho, Crisnaiara Cândido   +2 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

School Leadership for Social Justice: A Critique of Starratt\u27s Tripartite Model [PDF]

, 2007
Rather than treated as a discreet task or as an overarching orientation, leadership for social justice is more appropriately situated within a comprehensive theory of school administration, such as Starratt’s (2003) model of leadership as cultivating ...
Scanlan, Martin
core   +1 more source