Results 21 to 30 of about 30,293 (264)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

District administrator perspectives of current and ideal approaches to identifying and supporting student social, emotional, and behavioral needs

Frontiers in Education
IntroductionLeadership support has been identified as a key facilitator to successful implementation of school-based initiatives. School leadership contributions to student academic success and school reform have been documented, but less work has ...
Sandra M. Chafouleas, Dakota W. Cintron, Jessica B. Koslouski, Amy M. Briesch, D. Betsy McCoach, Jennifer N. Dineen   +5 more
doaj   +1 more source

School Safety Assessment: Responses from School Principal Interns

Northwest Journal of Teacher Education, 2020
School shootings in America occur with alarming frequency and little predictability or allowance for preparation and planning. This crisis demands attention and assessment from a variety of stakeholders, especially school leaders.
Cynthia Johnson
doaj   +1 more source

HOSPITAL AND TRAINING SCHOOL ADMINISTRATION [PDF]

AJN, American Journal of Nursing, 1919
n ...
Gilman, Alice Shepard, de Long, Katherine   +1 more
openaire   +1 more source

Determining the Characteristics of Leader School Administrators According to School Administrators

The Journal of Academic Social Resources, 2023
Bu araştırmanın temele amacı lider okul yöneticilerinde bulunması gereken özellikleri okul yöneticisi görüşlerine göre belirlemektir. Araştırma temel nitel araştırma desenine göre yürütülmüştür. Araştırmanın çalışma grubunu 2022-2023 eğitim öğretim yılında ilk ve orta dereceli okullarda okul yöneticisi olarak görev yapan 12 ...
Engin Yiğit, Alim Kılçar, Halil Alaylı   +2 more
openaire   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Qualifications of the Ideal Tourism School Administrator: A RepGrid Review

Yüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi
The school administrator has one of the most important roles in the success of an institution and in the execution of processes, especially in some fields like tourism including practical parts.
Yasemin Yetkin, Fatih Kancınar, Halil İbrahim Özok   +2 more
doaj   +1 more source

HOSPITAL AND TRAINING SCHOOL ADMINISTRATION [PDF]

AJN, American Journal of Nursing, 1916
n ...
Riddle, Mary M., Eldredge, Adda
openaire   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source