Results 111 to 120 of about 9,811,085 (297)

Differences in High-Frequency Connectivity Among Large-Scale Functional Networks Linked to Major Depressive Disorder and Treatment-Resistant Depression

Biological Psychiatry Global Open Science
Background: Major depressive disorder (MDD) and treatment-resistant depression (TRD) have each been characterized by altered neural connectivity largely associated with the triple model of the default mode (DMN), frontoparietal (FPN), and salience (SN ...
Ty Lees, Sarah E. Woronko, Mohan Li, Jason N. Scott, Jr., Manuel Kuhn, Shiba M. Esfand, Mario Bogdanov, Brian W. Boyle, Samantha R. Linton, Lauren R. Borchers, Peter Zhukovsky, Courtney Miller, Paula Bolton, Shuang Li, Robert C. Meisner, Diego A. Pizzagalli   +15 more
doaj   +1 more source

The Mediating Role of Mathematics Anxiety in the Relationship Between High School Students’ Metacognitive Awareness and Mathematical Resilience

The present study examined the mediating role of mathematics anxiety in the relationship between high school students’ metacognitive awareness and mathemati cal resilience. For this aim, a hypothetical model was proposed.
Nur Şebnem BAKIR, İlknur GÜLŞEN TURGUT   +1 more
core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Exploration of NMDA and GABA receptor-mediated plasticity induced by 10-Hz repetitive transcranial magnetic stimulation

Translational Psychiatry
Although 10-Hz repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression, we do not understand the mechanisms through which rTMS induces therapeutic change.
Jamie Kweon, Hakjoo Kim, Prem Ganesh, Megan M. Vigne, Andrew M. Fukuda, Boyu Ren, Linda L. Carpenter, Joshua C. Brown   +7 more
doaj   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Protocol for the Parent Anxiety Transmission and Habits (PATH) study: a randomised controlled trial testing parent interpretation bias as a key mechanism of intergenerational transmission of anxiety

BMJ Open
Introduction Anxiety disorders are the most common youth mental health problems in the USA. Most children do not receive treatment and among the few who do, many do not experience significant improvement.
Margaret A Chiffer, Daniel P Dickstein, Roni Itkin-Ofer, Jennie M Kuckertz, Boyu Ren, Doah E Shin, Alexandra L Silverman, Christian A Webb, Courtney Beard   +8 more
doaj   +1 more source

MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation

Advanced Science, EarlyView.
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui, Lin Mao, Binggang Li, Hanyue Kang, Zhengquan Tang, Sheng Chen, Hui Yang, Yu Qiao, Huiqian Ding, Yuhuan Wang, Min Li, Junjie Hu, Shoudong Ye, Xin Wang, Xiaobin Xu, Yupeng Wang, Tana Wuren, Qian Ban, Baowei Zhang   +18 more
wiley   +1 more source

Using Drift Diffusion and RL Models to Disentangle Effects of Depression On Decision-Making vs. Learning in the Probabilistic Reward Task

Computational Psychiatry
The Probabilistic Reward Task (PRT) is widely used to investigate the impact of Major Depressive Disorder (MDD) on reinforcement learning (RL), and recent studies have used it to provide insight into decision-making mechanisms affected by MDD.
Daniel G. Dillon, Emily L. Belleau, Julianne Origlio, Madison McKee, Aava Jahan, Ashley Meyer, Min Kang Souther, Devon Brunner, Manuel Kuhn, Yuen Siang Ang, Cristina Cusin, Maurizio Fava, Diego A. Pizzagalli   +12 more
doaj   +1 more source

School-based prevention of anxiety and depressive symptoms in children

, 2015
 This thesis examined school-based prevention of anxiety and depressive symptoms in children, focusing on the role of social comparisons, self-concepts and self-esteem.
Emily Rachel Prytula (13792483)
core