Results 121 to 130 of about 9,811,085 (297)

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

A Neutrophil Membrane‐Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age‐Dependent Perioperative Neurocognitive Disorders

Advanced Science, EarlyView.
This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang, Jiahui Cheng, Huan Xu, Qiang Zhang, Xiao Zhang, Ye Liu, Yizhe Zhang, Wanbing Dai, Zhi Xiong, Linghuan Guo, Lingling Xu, Wen Wang, Xin Xu, Yan Zhou, Weifeng Yu, Bo Li, Diansan Su, Daxiang Wen   +17 more
wiley   +1 more source

The Effect of Exercise on Anxiety of Adolescents with Intellectual Disability

Physical Treatments, 2015
Purpose: The present study aimed to investigate the effect of exercise on the anxiety of adolescents with intellectual disability. Methods: Study method was quasi-experimental with pretest-posttest design and a control group.
Masoomeh Salehpoor, Mohsen Salesi, Ghorban Hemati Alamdarloo   +2 more
doaj  

Role of the Locus Coeruleus in Response to Threat in Anxiety Disorders and Posttraumatic Stress Disorder: An Ultra-High-Field 7T Functional Magnetic Resonance Imaging Study

Biological Psychiatry Global Open Science
Background: By harnessing the enhanced spatial resolution and signal power of high-field 7T magnetic resonance imaging (MRI), we assessed the functional involvement of the locus coeruleus (LC), together with the broader threat circuitry, in anxious ...
Sarah C. Boukezzi, Philipp T. Neukam, Nicholas Balderston, Yael Jacob, Derek A. Smith, Yolanda Whitaker, Sarah B. Rutter, Vicki Soogrim, Adriana Feder, Dennis S. Charney, Christian Grillon, Prantik Kundu, Priti Balchandani, Laurel S. Morris, James W. Murrough   +14 more
doaj   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity

Nature Communications
Large-scale brain activity at rest is thought to wander among a discrete set of attractor-like functional configurations shaped by underlying structural connections, yet how state-transitions are perturbed in major depressive disorder remains unknown ...
B. Ülgen Kilic, Jenna Jubeir, Priti Balchandani, James W. Murrough, Laurel S. Morris, Yael Jacob   +5 more
doaj   +1 more source

Accelerated acupuncture therapy for patients with major depressive symptoms: a single blind, randomized wait-list controlled trial

Journal of Affective Disorders Reports
Aim: To test the effectiveness of an accelerated acupuncture treatment as an augmentation therapy for patients with primary diagnosis of major depressive symptoms.
Xiao Wei Tan, Yuen Yin Joyce Chee, Yin Jia Lim, Frederick Peiwei Koh, Zheng Jie Jovi Koh, Gulwant Hasvinjit Kaur Singh, Si Yun Rachel Tan, Linda Zhong, Phern Chern Tor   +8 more
doaj   +1 more source

Cybervictimization, Self-Concept, Aggressiveness, and School Anxiety in School Children: A Structural Equations Analysis. [PDF]

Int J Environ Res Public Health, 2020
Escortell R, Delgado B, Martínez-Monteagudo MC.   +2 more
europepmc   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Personality and cognitive factors implicated in depression and anxiety in multiple sclerosis: A systematic review and meta-analysis

Journal of Affective Disorders Reports
Background: Depression and anxiety are prevalent among persons living with multiple sclerosis (plwMS) and are linked to negative prognostic outcomes. Cognitive theories posit that personality and cognitive factors confer risk for depression and anxiety ...
Rebekah A. Davenport, Isabel Krug, Nicole Rickerby, Phuong Linh Dang, Elizabeth Forte, Litza Kiropoulos   +5 more
doaj   +1 more source