Results 81 to 90 of about 4,049,211 (314)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Educational Process: International JournalBackground/purpose. In multicultural societies, fostering social cohesion through education is essential to mitigating intolerance and conflict. While formal tolerance education is common, its effectiveness in shaping inclusive attitudes remains limited.
Abdurrohman +3 more
doaj +1 more source
Psychological school climate: on the structure of the notion [PDF]
Современная зарубежная психология, 2015 The article regards the structure of the notion "school structure". The traditionally singled out components of school climate — structure and culture — are amended by the notion of an "individual", which becomes central for the concept of school ...
Fedunina N.Y.
doaj
Perceptions of Effectiveness of School Counselors with Former Graduates in a TRIO College Program [PDF]
, 2016 The context and variables that affect at-risk students are constantly changing. It is imperative that school counselors understand the risk factors for students and the cultural and social contexts the individual lives within.
Colton, Emily +4 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Can neuroscience construct a literate gendered culture? [PDF]
, 2011 The construction of boys as a gendered culture is not usually associated with neuroscience. Exceptions are publications and presentations by consultants on boys’ education who adopt a “brain-based” perspective.
Whitehead, David
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Culture Change: The Work of C.A. Bowers in Educational Policy [PDF]
, 1988 C.A. Bowers has proposed a perspective on educational theory and practice involving cultural literacy and communicative competence. Bowers\u27 proposal addresses culture change through a critical examination of activities in the school curriculum.
Johnson, Nancy R.
core +1 more source
When caring hurts: “Foreign” teachers in Texas bilingual classrooms [PDF]
, 2018 As the U.S. teacher shortage continues to worsen, large, urban districts have turned to hiring teachers from abroad, including countries like Spain, Mexico, and the incorporated U.S. territory of Puerto Rico.
Batista-Morales, N.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source