Results 111 to 120 of about 6,542,132 (309)

The grounded projection: A reflective examination of urban design pedagogy at Melbourne School of Design

open access: yesJournal of Design for Resilience in Architecture and Planning
Urban design education faces unprecedented challenges as ecological emergencies, socio-political risks and technological transitions converge to reshape cities worldwide.
Onur Tümtürk   +3 more
doaj   +1 more source

“Sustainability” Education by Sustainable School Design

open access: yesProcedia - Social and Behavioral Sciences, 2015
AbstractIn recent years, sustainability concept has become the common interest of numerous disciplines. The reason for this popularity is, to perform the sustainable development of societies. Easiness of forming a relationship with the word “sustainability” is because of its social, economic and environmental aspects.
openaire   +3 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Design and implementation of a platform for smart connected school buildings [PDF]

open access: yes, 2015
We have designed and implemented a platform that enables monitoring and actuation in multiple buildings, that has been utilised in the context of a research project in Greece, focusing on public school buildings.
Amaxilatis, D.   +2 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Assessing driver distraction from in-vehicle information system: an on-road study exploring the effects of input modalities and secondary task types

open access: yesScientific Reports
In-vehicle information system (IVIS) use is prevalent among young adults. However, their interaction with IVIS needs to be better understood. Therefore, an on-road study aims to explore the effects of input modalities and secondary task types on young ...
Qi Zhong   +4 more
doaj   +1 more source

The New Building on the Block [PDF]

open access: yes, 2000
Members of the Building Committee relied on the expertise and input from faculty and staff to use the building\u27s design and architecture to enhance the School of Law\u27s sense of ...
Leary, Betty Lynne
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

‘Bag for Life’ – using multidisciplinary approaches in design pedagogy to develop global citizenship [PDF]

open access: yes, 2010
As the need to integrate approaches to sustainable thinking and global citizenship becomes ever more pressing, a multi disciplinary project has been initiated at Northumbria University's School of Design to address these issues.
Ghassan, Aysar, Rowe, Gill
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

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