Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Growing Opportunity: A Two-Year Update on The Opportunity Equation: Transforming Mathematics and Science Education for Citizenship and the Global Economy [PDF]
, 2011 Highlights progress on a 2009 report's call to mobilize for innovative, accountable math and science education for all; establish clear standards and effective assessments; improve teacher supply and leadership; and enhance school and system ...
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Characteristics of Private Schools in the United States: Results From the 2011-12 Private School Universe Survey [PDF]
, 2013 In 1988, the National Center for Education Statistics (NCES) developed a private school data collection that improved on the sporadic collection of private school data dating back to 1890 bydeveloping an alternative to commercially available private ...
Nancy L. Swaim, Steven P. Broughman
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Impacts of active school design on school-time sedentary behavior and physical activity: A pilot natural experiment. [PDF]
PLoS One, 2017 Brittin J +8 more
europepmc +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Healthy School, Happy School: Design and Protocol for a Randomized Clinical Trial Designed to Prevent Weight Gain in Children. [PDF]
Arq Bras Cardiol, 2017 Schuh DS +6 more
europepmc +1 more source
, 2019 2018 senesinde Türk hükümeti çesitli sebeplerle lise yerlestirme sistemini degistirmistir.Bir dizayncı olarak hükümet, ögrencilerin büyük bir çogunlugu için tammerkezi bir sistemde sıralamalara göre yerlestirilecek okulların yerine lokasyonlaragöre ögrencilerin yerlestirilecegi mahalle liseleri kurmayı hedeflemistir.
openaire +1 more source
An illustration of web survey methododlogy [PDF]
, 2009 A former study in the Danish primary schools has shown that there is an association between organic school food policies and indicators (proxies) for healthy eating among children when (school food coordinators) statements on indicators (proxies) for ...
He, Chen
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