Results 101 to 110 of about 3,082,840 (310)

Assessing the properties of patient-specific treatment effect estimates from causal forest algorithms under essential heterogeneity

BMC Medical Research Methodology
Background Treatment variation from observational data has been used to estimate patient-specific treatment effects. Causal Forest Algorithms (CFAs) developed for this task have unknown properties when treatment effect heterogeneity from unmeasured ...
John M. Brooks, Cole G. Chapman, Brian K. Chen, Sarah B. Floyd, Neset Hikmet   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

國中教師知識管理對學校效能影響之研究 The Influence of Junior High School Teachers’ Knowledge Management on School Effectiveness

Shizi Peiyu Yu Jiaoshi Zhuanye Fazhan Qikan, 2008
本研究旨在探討知識管理與學校效能的重要內涵與構面；並瞭解國中兼任行政職務教師的知識管理對學校效能之影響，以作為提昇學校效能之參考。本研究以台中市之公立國民中學教師兼任行政職務301 人為對象，採問卷調查方式，其研究結果如下：（一）知識管理可以分為知識的取得、知識的儲存、知識的應用、知識的分 享、知識的創新5 個構面，及25 個指標。（二）學校效能可以分為學生學習表現、教師教學品質、行政績效表現、校園環境設備、社區家長支持5 個構面，及25 個指標。（三）國中兼任行政職務教師需具備充分的知識管理能力 ...
陳聰文 Chen, Tsong-Wen, 林素卿Lin, Su-Ching, 龔心怡Kung, Hsin-Yi   +2 more
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Strengthening School Effectiveness Through Collaborative Working : An Evaluation of Training Impact

Jurnal Paedagogy
This study aims to examine the effectiveness of experiential learning-based collaborative working training in enhancing the collaborative competence of stakeholders in elementary school setting.
Yushi Widya Pramita, Tjut Rifameutia
doaj   +1 more source

Tracking pupil mobility over the pre-school and primary school period: evidence from EPPE 3-11 [PDF]

, 2008
This report describes the ‘tracking’ of the EPPE 3-11 sample and then goes on to examine the possible influence of mobility on EPPE 3-11 children’s cognitive progress and social/behavioural development over both the pre-school and primary school ...
Barreau, S., Hunt, S., Melhuish, Edward C., Sammons, P., Siraj-Blatchford, I., Sylva, K., Taggart, B., Welcomme, W.   +7 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Measuring School and Teacher Academic Optimism in Diverse School Contexts The Validation of the adapted Survey for Academic Optimism

Pedagogische Studiën, 2022
Academic optimism is the reflection of a triadic set of interactions between efficacy, trust, and academic emphasis, which positively correlates with students’ performance, also after controlling for previous performance, SES and other demographic ...
R. Lelieur, N. Clycq, J. Vanhoof
doaj