Results 131 to 140 of about 3,082,840 (310)

School Effectiveness Framework pilots: an evaluation (research document) [PDF]

open access: yes, 2010
"This report looks at the pilot to introduce the School Effectiveness Framework in schools in Wales. The School Effectiveness Framework (SEF) is an ambitious Welsh Assembly Government (WAG) programme that aims to raise attainment, to close the gap in ...
Holtom, Duncan, Lloyd-Jones, Sarah
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Infrastructure Choices in Education: Location, Build or Repair [PDF]

open access: yes
The purpose of this study is to develop a model to arrive at a joint optimizing strategy for the use of a given capital budget for the construction of new school buildings and for the repair of the already existing schools.
Andrey Klevchuk   +2 more
core  

A Review of Disciplinary Interventions in K12 Public Education [PDF]

open access: yes, 2018
As a part of the Achieving Racial Equity in School Disciplinary Policies and Practices study from the Metropolitan Educational Research Consortium, this literature brief offers an overview of school discipline interventions in K12 public education.
Coffee, Mariah   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

The effectiveness of English secondary schools for pupils of different ability levels [PDF]

open access: yes
'League table' information on school effectiveness in England generally relies on either a comparison of the average outcomes of pupils by school, e.g. mean exam scores, or on estimates of the average value added by each school.
Anna Vignoles   +2 more
core   +3 more sources

Public spending on education: Its impact on students skipping classes and completing school [PDF]

open access: yes
Empirical results using cross-country data suggest that public spending on education increases the rate of students skipping school but does not influence the rate of students completing school.
Yamamura, Eiji
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Your PEL questionnaire development - evaluation of the impact of health education programs in schools. [PDF]

open access: yes, 2019
Artigo apresentado em Coimbra no âmbito do Anuual Meeting 2019 da Escola Superior de Tecnologia da SaúdeThe Your PEL project emerged in response to requests from regional school groups and community care units that have identified the need to assess the ...
Amendoeira, José   +9 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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