Results 191 to 200 of about 3,120,187 (310)

Evaluating the outcomes of a school-based intervention on water, sanitation, and hygiene practices in urban slums of Nigeria: a qualitative evaluation based on implementation research outcome frameworks. [PDF]

BMC Public Health
Ezenwaka U, Ikeako KL, Onwujekwe O.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Promoting CHANGE cluster randomised controlled trial to improve food outlet healthiness in Australian sport and recreation facilities: protocol. [PDF]

BMJ Open
Lalchandani N, Romaniuk H, Cameron A, Orellana L, Ananthapavan J, Peeters A, Backman B, Adam M, Allender S, Nguyen P, Sacks G, Brimblecombe JK, McMahon E, Blake M.   +13 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Healthy school recognized campus: design and methodology of a hybrid type 2 implementation-effectiveness cluster randomized trial. [PDF]

Implement Sci
Schaefers A, Beattie CM, de Mello GT, George A, Marstall K, Gardner J, Szeszulski J.   +6 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Multiphase optimization implementation strategy for tobacco cessation interventions in primary care clinics: A cluster-randomized type 3 hybrid effectiveness-implementation trial. [PDF]

Tob Induc Dis
Chen J, Yang J, Liu S, He W, Chen X, Cai Y, Tong G, Zhou H, Luo H, Luo L, Xu D.   +10 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Effectiveness and Cost-Utility of Anti-Adhesion Agents in Intra-Abdominal Surgery Patients. [PDF]

J Korean Med Sci
Lee YS, Park S, Park M, Ha US, Lee SJ, Lee TJ, Shin E.   +6 more
europepmc   +1 more source