Results 61 to 70 of about 3,822,591 (268)
Child and Adolescent Psychiatric Clinics of North America, 1998 The Comer School Development Program (SDP) has received considerable national attention over the last decade. The authors describe the origins, central tenets, and principles of the SDP. Although the Comer model is a systemic one, one of its primary foci is the developmental and mental health needs of children attending urban schools.
J P, Comer, D W, Woodruff
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
آموزش بهداشت و ارتقاء سلامت ایران, 2018 Background and objective: one of the major causes of child mortality is road traffic injuries. Police-assistant students are the students, who receive education on basic and simple contents of road traffic incidents.
Forouzan Rezapur-Shahkolai +3 more
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Physical activity and body mass index in colombian schoolchildren. Multicenter study
Hacia la Promoción de la Salud, 2018 To establish the relationship between levels of physical activity and body mass index in Colombian students. Materials and methods: Correlational descriptive study, performed with 2,651 children between 10-12 years of age, educated in both public and ...
José Armando Vidarte Claros +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Indicadores de aptidão física de escolares da região centro-oeste da cidade de São Paulo
Revista Brasileira de Cineantropometria e Desempenho Humano, 2010 Os objetivos deste estudo foram: a) mensurar indicadores de aptidão física em crianças e adolescentes, de acordo com a idade cronológica e o sexo; b) classificar seu desempenho por meio das tabelas normativas do PROESP-BR.
Carla Nascimento Luguetti +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source