Results 91 to 100 of about 3,591,556 (312)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

System leadership for school improvement: A developing concept and set of practices [PDF]

, 2016
System'leadership'is'a'developing'concept'and'practice'increasingly'seen'as'a' tool'for' school' improvement,' as' policy'makers' switch'from'traditional'top?down' reform' to' professional' models' of' schools' working' collaboratively.' System ...
Dimmock, Clive
core  

Systems of education governance and cultures of justice in Ireland, Scotland and Pakistan [PDF]

, 2019
This chapter compares the issue of cultures of justice in the systems of education governance in three education systems: Ireland, Scotland and Pakistan. The focus for the comparison are the current policies which shape the regulation of education. These
A Keddie, Annual Status of Education Report Pakistan (ASER), C Hudson, Central Statistics Office, D Torrance, Department of Education and Skills, Department of Education and Skills (DES), Department of Education and Skills (DES), Department of the Taoiseach, I Bache, I Berkovich, J DeStefano, J Lumby, J Razzaq, J Razzaq, M Arnott, M Lall, MB Miles, Parliament of the UK (PoUK), PF Conway, R Rinne, R Shamir, S Grek, SJ Ball, SJ Ball, T Rahman, TM Skrtic, Y Zaidi   +27 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

IMPROVEMENT MANAGEMENT OF TEACHER RESOURCE AMONG VOCATIONAL HIGH SCHOOL BASED ON INTERNATIONAL STANDARD SCHOOL INVEST (INDONESIA VOCATIONAL EDUCATION STRENGTHENING) IN YOGYAKARTA [PDF]

, 2012
This education research aimed to: (1) find an overview of resource about teacher’s resource improvement management in vocational high school based on international INVEST in Yogyakarta, (2) find the effectiveness for the implementation of quality ...
Dian Rustamana Indra Putra, Dian Rustamana Indra Putra
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Generating Innovative Ideas for School Improvement: An Examination of School Principals

Education Sciences
The purpose of this exploratory study was to examine school principals’ tendencies and practices that bring forth innovative ideas for school improvement.
Miguel M. Gonzales, Tiberio Garza, Elizabeth Leon-Zaragoza   +2 more
doaj   +1 more source

Educational achievement and ethnicity in compulsory schooling [PDF]

, 2008
This paper analyzes the evolution of the attainment gap between white British born and ethnic minority pupils throughout compulsory schooling, from the age of 5 to 16. At the start of school, pupils from most ethnic groups substantially lag behind White
Dustmann, C., Machin, S.J., Schonberg, U.   +2 more
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