Results 101 to 110 of about 3,591,556 (312)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

An SEA Guide for Identifying Evidence-Based Interventions for School Improvement [PDF]

, 2016
The Every Student Succeeds Act (ESSA) is the most recent reauthorization of the Elementary and Secondary Education Act and replaces the No Child Left Behind Act (NCLB).
Barbara Foorman, John Hughes, Kevin Smith, Laurie Lee   +3 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

L’approccio culturale alla formazione in servizio degli insegnanti

Science & Philosophy, 2014
In the text presented below the two key words: the culture based approach and teachers’ in-service education are structured in terms of relationship embedded in the current scenario where schools interface with new and complex problems.
Grazia Angeloni
doaj  

Teacher data literacy: a scoping review (2020–2024)

Cogent Education
Recent trends in school improvement and teacher education have emphasised the crucial role of data and the importance of preparing teachers to read, interpret and use it to inform their practice. It has been demonstrated that the effective use of data by
Serafina Pastore
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Preparing improvement teams to manage complex change in a continuous improvement program

Frontiers in Education
This study is a cross-case comparison of three cohorts of teams of educators implementing a continuous improvement program in partnership between a university and a district.
Erin Anderson
doaj   +1 more source

Beyond School Closings: Effective Alternatives for Low-Performing Schools [PDF]

, 2010
Parents from low-income and working-class communities in New York City have been fighting for years for dramatic improvements in struggling neighborhood schools.

core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An investigation of authentic leadership and teachers’ organizational citizenship behavior in secondary schools of Pakistan

Cogent Education, 2018
This study is based on the premise that in order to create better schools, good leadership must be developed. This study believes that Authentic Leadership (AL), as propounded by various authors in the past 15 years, provides a useful framework for ...
Uzma Quraishi, Fakhra Aziz
doaj   +1 more source