Results 21 to 30 of about 202,153 (252)
Desarrollo curricular y recursos educativos en las bibliotecas escolares
Investigaciones Sobre Lectura, 2017 The aim of this study is to evaluate the curricular development and educational resources of the school libraries in Málaga. The provincial coordination of the Educational Local Office has carried out- since the academic course 2008/2009- an annual ...
Inmaculada Santos Díaz
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
TECA, 2021 The project features a methodological scheme, structured but flexible, easily adaptable to different contexts, projects, and situations. The scheme, supporting the library planning, is intended to be a useful tool to design and manage initiatives ...
Luisa Marquardt +2 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Various Factors May Influence High School Student Use of Public Libraries
Evidence Based Library and Information Practice, 2013 Objective – To discover the factors that influence frequency of high school students’ usage of public libraries. Design – Structural equation modeling (SEM) using the person-in-environment (PIE) framework to test latent variables and direct and ...
Robin E. Miller
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Public libraries and school libraries: Major differences
TransinformaçãoPublic and school libraries in Brazil have not yet been universalized. Many are in a precarious state, and their functions are often confused. In order to demonstrate that such reality persists, some projects that were submitted to an Official ...
Marilia de Abreu Martins de PAIVA +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Knjižnica, 2001 The bibliometrical analysis of publications on school libraries in library and education serials in the years 1945 – 1999 considers 739 bibliographical units.
Franceska Žumer, Primož Južnič
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