Results 51 to 60 of about 5,637,703 (284)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

School Library Advocacy Literature in the United States

open access: yesIASL Annual Conference Proceedings, 2015
Despite evidence of school librarians’ impact on student achievement and multiple advocacy efforts, position eliminations and budget reductions continue across the United States.
A. Ewbank, J. Kwon
semanticscholar   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Iniciativas y proyectos para fortalecer la biblioteca escolar en Colombia: una revisión histórica. Del siglo XIX al siglo XXI

open access: yesRevista Interamericana de Bibliotecología, 2017
This study conducted a review of government initiatives and projects aimed at strengthening school libraries in the country, with special emphasis in the city of Medellin, from the 19th century to the second decade of the 21st century.
Sandra Patricia Bedoya Mazo
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

La evaluación del desempeño del bibliotecario escolar en la agenda del director de la institución educativa

open access: yesRevista Interamericana de Bibliotecología, 2011
Una biblioteca es exitosa cuando se convierte en punto neurálgico de un centro escolar. Para ello debe flexibilizar sus espacios de aprendizaje, generando proyectos de trabajo que inciten a la recreación, las prácticas de lectura, la alfabetización ...
Nélida Alcira Garciarena   +1 more
doaj  

Analisis dan Perancangan Sistem Informasi Perpustakaan Sma Negeri Xyz

open access: yesComTech, 2014
Library information system analysis and design for public senior high school XYZ in South Tangerang aims to identify needs of data and information about library operational transaction in the school.
Titan Titan   +2 more
doaj   +1 more source

Atividades de fãs e fandoms na biblioteca escolar: mediações alinhadas aos programas e atividades das diretrizes da IFLA para a biblioteca escolar

open access: yesPáginas a&b, 2020
The research problem consists on the following question: how to structure an information mediation activity to work with fan and fandoms activities in school libraries?
Everton da Silva Camillo   +1 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

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