Results 101 to 110 of about 6,536,177 (306)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Image processing in the conservation of historic urban areas: the case of Dujiangyan, China
Built HeritageUnderstanding the historical evolution of spatial layout and architectural styles in a historic area is imperative for its preservation and rejuvenation.
Dongqi Li +4 more
doaj +1 more source
Structures of policy : Building Bulletin in Postwar Britain [PDF]
, 2016 School design in Great Britain underwent great typological change in the post-war era, necessitated by depleted construction labour and materials, coupled with a bourgeoning school-age population resulting from the population boom and an expanded student
Lang, Ruth
core
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Human-computer interaction interface design of flight simulator based on situation awareness
Scientific ReportsTo meet the comprehensive requirements of drivers for Human-Computer Interaction (HCI) during operation and to enhance situation awareness (SA), this paper proposes a design and evaluation method for flight simulator HCI interfaces grounded in SA ...
Zhengyi Shen +6 more
doaj +1 more source
RISD Faculty Values Statement [PDF]
, 2017 After thoughtful consideration and refinement of the 2017 RISD Faculty Values Statement, the full-time faculty, several part-time faculty and RISD Museum curators voted in favor of its contents and have signed on as supporters.
Rhode Island School of Design
core +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
, 2016 Official Collection 2016 Program distributed at the ...
Rhode Island School of Design
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source