Results 111 to 120 of about 6,536,177 (306)
The Founding of an Urban Charter School: Three Years of Academic Growth and Key School Characteristics [PDF]
, 2016 The Kauffman School is a public charter school that serves students from low-income neighborhoods in Kansas City, Missouri. This paper used a matched comparison group design to estimate the impacts of the Kauffman School on student achievement ...
Ava Madoff +4 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Effects of Kindergarten and First Grade Schooling on Executive Function and Academic Skill Development: Evidence From a School Cutoff Design. [PDF]
Front Psychol, 2020 Kim MH, Ahmed SF, Morrison FJ.
europepmc +1 more source
, 2015 Official Collection 2015 Program distributed at the ...
Rhode Island School of Design
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Product design improvement method driven by online product reviews
Scientific ReportsCustomer-centered design plays a crucial role in achieving sustainable design by aligning product features with actual customer needs, promoting resource efficiency, and supporting environmental protection.
Fang-Min Cheng +4 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Scientific DataThis paper describes a two-year high-fidelity dataset for an ultra-low energy office building and living laboratory called HouseZero ®. The building integrates multiple low-energy technologies, such as natural ventilation with automatic windows, ground ...
Jung Min Han +7 more
doaj +1 more source
The New Building on the Block [PDF]
, 2000 Members of the Building Committee relied on the expertise and input from faculty and staff to use the building\u27s design and architecture to enhance the School of Law\u27s sense of ...
Leary, Betty Lynne
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