Results 61 to 70 of about 9,436,951 (302)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

School violence and the effect on the guidance counselor's role [PDF]

, 2004
Plan BThe purpose of this study was to determine if there have been changes in the high school counselor’s role and function due to crises and violence in schools.
Anderson, Brandon
core  

Using extreme risk protection orders to prevent violence among people experiencing homelessness in California and Colorado: a case series

Injury Epidemiology
Background Extreme Risk Protection Orders (ERPOs) temporarily restrict firearm access from those at risk of harming themselves and/or others. This case series describes when and how ERPOs have been used for people experiencing homelessness.
Ari Davis, Rose Kim, Lisa B. Geller, Christopher E. Knoepke, Leslie Barnard, Garen J. Wintemute, Veronica A. Pear   +6 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The relationship between school violence, childhood anger, and the use of preventions and interventions in schools [PDF]

, 2002
Plan BSchool violence has been an important topic in the realm of education in the last decade, and many different acts of violence in schools have been witnessed. Most of these acts of violence have been perpetrated by students of those schools. Schools
Peper, Erin S.
core  

Risk factors for maladaptive grief and posttraumatic stress in children and adolescents following loss: a systematic review

Child and Adolescent Psychiatry and Mental Health
Background Traumatic losses in childhood and adolescence can evoke both maladaptive grief symptoms (MGS) and posttraumatic stress symptoms (PTSS). The aim of this study was to systematically review the existing literature to identify which risk factors ...
Philipp Jann, Neele Winkler, Harald Karutz, Veronika Hulde, Tobias Hecker   +4 more
doaj   +1 more source

Effects of exposure to community violence and family violence on school functioning problems among urban youth: The potential mediating role of posttraumatic stress symptoms

Frontiers in Public Health, 2014
Adolescents who are exposed to violence during childhood are at an increased risk for developing posttraumatic stress (PTS) symptoms. The literature suggests that violence exposure might also have negative effects on school functioning, and that PTS ...
Tia eMcGill, Shannon R Self-Brown, Betty S. Lai, Melissa eCowart, Ashwini eTiwari, Monique eLeBlanc, Mary Lou eKelley   +6 more
doaj   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source