Results 51 to 60 of about 291,016 (240)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Estamos Ensinando o que É Necessário sobre Doenças Reumatológicas?

Revista Brasileira de Educação Médica
Condições musculoesqueléticas foram identificadas como a principal causa de dor crônica e incapacidade em todo o mundo. É necessário que o estudante de Medicina entre em contato com as doenças mais frequentemente observadas na prática diária, a fim de se
Pedro Albuquerque Rebello, Thiago Damasceno Corrêa, Igor Beltrão Duarte Fernandes, Cezar Augusto Muniz Caldas   +3 more
doaj   +1 more source

Teaching psychiatry to large groups in society

BMC Medical Education, 2019
Background There is a need to educate a range of professionals in caring for individuals with long-term mental disability who reside within our communities. Empathy alone is insufficient.
Susanne Bejerot, Ann Lindgren, Jörgen Rosén, Eva Bejerot, Marie Elwin   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Evaluación por competencias en la educación médica

Revista Peruana de Medicina Experimental y Salud Pública
En la actualidad, se considera al modelo curricular por competencias el más apropiado para la educación médica. Mucho se ha escrito sobre este modelo curricular, sin embargo, un aspecto crucial es la evaluación del desarrollo de las competencias, este es
Denisse Champin
doaj  

Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease

Scientific Reports, 2017
This study investigated the relationships among plasma biomarkers, regional brain atrophy, and clinical symptoms in patients with Alzheimer’s disease (AD; n = 177), mild cognitive impairment (MCI; N = 60) and controls (n = 108).
Jung-Lung Hsu, Wei-Ju Lee, Yi-Chu Liao, Jiing-Feng Lirng, Shuu-Jiun Wang, Jong-Ling Fuh   +5 more
doaj   +1 more source

Physical activity and the prevention, reduction, and treatment of alcohol and/or substance use across the lifespan (The PHASE review): protocol for a systematic review

Systematic Reviews, 2018
Background Alcohol and substance use results in significant human and economic cost globally and is associated with economic costs of £21 billion and £15billion within the UK, respectively, and trends for use are not improving.
Tom P. Thompson, Adrian H. Taylor, Amanda Wanner, Kerryn Husk, Yinghui Wei, Siobhan Creanor, Rebecca Kandiyali, Jo Neale, Julia Sinclair, Mona Nasser, Gary Wallace   +10 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Factors affecting the concentrations of heavy metals in precipitation of Tehran using factor analysis method

سلامت و محیط, 2016
Backgrounds and Objectives: Quantity of trace metals in the wet precipitation can illustrate the environmental pollution of different urban areas. Up to now, there is no study regarding the chemistry of wet precipitation in Tehran .The objectives of this
H Kamani, M Hoseini, G.H Safari, A.H Mahvi, H Zarei   +4 more
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source