Results 251 to 260 of about 3,339,817 (343)

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

On a class of conservative, highly accurate Galerkin methods for the Schrödinger equation

, 1991
Georgios Akrivis, Vassilios A. Dougalis
openalex   +1 more source

Identification and structural characterization of a novel acetyl xylan esterase from Aspergillus oryzae

The FEBS Journal, EarlyView.
A novel acetyl xylan esterase was discovered from Aspergillus oryzae. The deacetylase activity toward wheat arabinoxylan increased synergistically with xylanase addition. The crystal structure exhibited hybrid features between two α/β‐hydrolase families, highlighting its structural uniqueness.
Chihaya Yamada, Tomoe Kato, Yoshihito Shiono, Takuya Koseki, Shinya Fushinobu   +4 more
wiley   +1 more source

Application of Schrödinger equation in quantum well of Cu₂ZnSnS₄ quaternary semiconductor alloy. [PDF]

Heliyon, 2020
Onate CA, Ebomwonyi O, Olanrewaju DB.
europepmc   +1 more source

Exact field ionization rates in the barrier-suppression regime from numerical time-dependent Schrödinger-equation calculations [PDF]

, 1999
D. Bauer, P. Mulser
openalex   +1 more source

Shifting the substrate scope of dimeric pyranose oxidase from monosaccharide to glycoside preference through oligomeric state modification

The FEBS Journal, EarlyView.
Pyranose oxidase (POx) and C‐glycoside oxidase (CGOx) are FAD‐dependent oxidoreductases that share the same sequence space. POxs with a higher oligomerization state exclusively catalyze the oxidation of monosaccharides, whereas monomeric POxs/CGOxs show preference towards glycosides. We engineered the dimeric POx from Kitasatospora aureofaciens (KaPOx)
Anja Kostelac, Enikő Hermann, Clemens Peterbauer, Chris Oostenbrink, Dietmar Haltrich   +4 more
wiley   +1 more source

Local Well-Posedness of the Periodic Nonlinear Schrödinger Equation with a Quadratic Nonlinearity u ¯ 2 in Negative Sobolev Spaces. [PDF]

J Dyn Differ Equ
Liu R.
europepmc   +1 more source

Formation of stationary localized states due to nonlinear impurities using the discrete nonlinear Schrödinger equation [PDF]

, 1997
Bikash C. Gupta, K. Kundu
openalex   +1 more source

Structure predictions of MuRF1‐UBE2 complexes identify amino acid residues governing interaction selectivity for each MuRF1‐E2 pair

The FEBS Journal, EarlyView.
MuRF1 is a major regulator of muscle atrophy, a side effect of chronic pathologies. As a RING‐type E3, MuRF1 depends on E2 enzymes to synthesize ubiquitin chains on substrates. MuRF1 can interact with four E2 enzymes, suggesting different physiological functions depending on the MuRF1‐E2 pair.
Agnès Claustre, Mélodie Malige, Maëlys Macheton, Lydie Combaret, Etienne Lefai, Pierre Fafournoux, Daniel Taillandier, Julien Henri, Cécile Polge   +8 more
wiley   +1 more source

Analytic Solutions to Nonelliptic Nonlinear Schrödinger Equations

, 1993
A. Debouard
openalex   +1 more source