Results 131 to 140 of about 19,010 (265)

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong   +7 more
wiley   +1 more source

Sustainability Assessment: The Role of Entropy‐Based Indicators for Reconnecting Human' Subjectivity and Civilization With Natural Tendency of Ecosystems

open access: yesSustainable Development, EarlyView.
ABSTRACT Sustainability represents a complex issue in which scientific knowledge inevitably coexists with the subjective perception of humans in its turn influenced by civilization, cultural but also unconscious aspects. These results emerge with evidence from a critical analysis of the main definitions of sustainability delivered by credited entities (
Francesco Di Maria, Hamid Safarzadeh
wiley   +1 more source

Dibenzofuran‐Modulated Narrowband Red MR‐TADF Emitters for BT.2020 OLEDs With Ultralow Roll‐Off and Long Lifetime

open access: yesSmall, EarlyView.
A materials‐to‐device strategy enabling high‐efficiency, longer‐lifetime narrowband red OLEDs. Dibenzofuran‐integrated BNO MR‐TADF emitters provide tunable red emission (611–633 nm) with high color purity. Exciplex‐assisted PSF devices achieve 31.6% EQE, <1% roll‐off at 5000 cd m−2, and LT90 584 h @ 5000 cd/m2.
Meghana Tirupati   +7 more
wiley   +1 more source

The photoswitchable ABAMIs for the future regulation of GWT1 in a spatiotemporal level

open access: yesSmart Molecules, EarlyView.
The GWT1‐targeted azobenzene‐aminopyridine derivatives (ABAMIs), sensitive to the light at wavelengths from 365 to 520 nm, are separately developed as photochromic ligands to regulate bioactivity as well as the GWT1 functions. These molecules are smart tools in photopharmacological studies, giving an innovative method for understanding functional GWT1 ...
Qian Ding   +8 more
wiley   +1 more source

Fine‐tuning ab initio XANES spectra calculations using the Bayesian optimization algorithm

open access: yesJournal of Synchrotron Radiation, EarlyView.
A Bayesian optimization technique is used to tune the FEFF and FDMNES packages and to improve matching between theoretical and experimental spectra. The tests were performed on monometallic Ni, Fe and Pd K‐edge XANES spectra using several different spectrum similarity metrics.Theoretical modeling of X‐ray absorption near‐edge structure (XANES) spectra ...
Andrey A. Sapronov   +2 more
wiley   +1 more source

Diverse DTPA‐chelated lanthanides with relevance for nuclear medicine bound to an engineered lipocalin reveal conserved ligand geometry

open access: yesActa Crystallographica Section F, EarlyView.
Structural and binding studies of the engineered lipocalin CL31d towards the chelate complexes of 11 different lanthanide and main‐group metal(III) ions, whose radioisotopes are useful for nuclear medicine, with a functionalized DTPA revealed a surprisingly broad tolerance towards varying ionic radii, thus enabling flexible radionuclide‐targeting ...
Alina Mirwald   +2 more
wiley   +1 more source

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