Results 141 to 150 of about 19,010 (265)

On the solution of Wave-Schrodinger equation

open access: yesJournal of Nonlinear Sciences and Applications, 2020
openaire   +2 more sources

Targeting hexokinase 2 to induce breast cancer cell senescence

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof   +8 more
wiley   +1 more source

Decoding functional specialization in G protein‐coupled receptors (GPCRs) through evolution‐guided residue profiling

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are integral membrane proteins that mediate physiological processes by enabling cells to detect and respond to diverse stimuli. Although many subfamily‐specific functional hotspots have been described, the family‐wide determinants of common and subfamily‐specific functions remain incomplete ...
Berkay Selçuk   +3 more
wiley   +1 more source

EvolvED: Evolutionary Embeddings to Understand the Generation Process of Diffusion Models

open access: yesComputer Graphics Forum, EarlyView.
EvolvED visualises how diffusion models generate images by embedding intermediate outputs to preserve semantics and evolutionary structure. It supports analysis via (a) user‐defined goals and prompts, (b) sampling intermediate images, (c) extracting relevant features, and (d) visualising them in structured radial and rectilinear layouts for ...
Vidya Prasad   +5 more
wiley   +1 more source

KU80 suppresses endonuclease G activity to preserve genomic integrity

open access: yesThe FEBS Journal, EarlyView.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan   +8 more
wiley   +1 more source

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