Results 181 to 190 of about 39,475 (232)
Acta Crystallographica Section D, Volume 82, Issue 5, Page 457-470, May 2026.Flavodiiron proteins (FDPs) are di‐iron enzymes that reduce NO and/or O2 with distinct substrate selectivity. We have produced E. coli FDP variants targeting second coordination‐sphere residues and determined their structures. Although the kinetics remained unchanged, the E.
Patrícia T. Borges +8 more
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Alphafuser: a parsimonious approach to predicting higher‐order protein complexes
Acta Crystallographica Section D, Volume 82, Issue 5, Page 421-433, May 2026.Alphafuser is a structure‐prediction pipeline that integrates experimental interaction data with AlphaFold‐based modeling to systematically assemble multiprotein complexes in a computationally efficient manner. By implementing an ipTM‐based pruning algorithm and validating against known structures and experimental assays, Alphafuser enables the ...
Audrey Guillotin +5 more
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Molecular Ecology Resources, Volume 26, Issue 4, May 2026.ABSTRACT Spiders are renowned for their ecological versatility and silk‐based innovations in materials science, yet marine environments remain virtually uncolonized by this predominantly terrestrial lineage. A striking exception is the obligate intertidal spider genus Desis, whose members have evolved extraordinary physiological and behavioural ...
Fan Li +11 more
wiley +1 more source
Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1
British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim +10 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT As diabetes has become an important public health issue, Lonicerae Japonicae Flos (LJF) had gradually attracted increasing attention on diabetes. This study aimed to investigate the hypoglycemic ingredients and underlying mechanisms of LJF in diabetes using an integrated strategy of network pharmacology, molecular docking and experimental ...
Zhang Nan +5 more
wiley +1 more source
Maximally dissipative and self‐adjoint extensions of K$K$‐invariant operators
Bulletin of the London Mathematical Society, Volume 58, Issue 5, May 2026.Abstract We introduce the notion of K$K$‐invariant operators, S$S$, in a Hilbert space, with respect to a bounded and boundedly invertible operator K$K$ defined via K∗SK=S$K^*SK=S$. Conditions such that self‐adjoint and maximally dissipative extensions of K$K$‐invariant symmetric operators are also K$K$‐invariant are investigated.
Christoph Fischbacher +2 more
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The principles of systems biology
Experimental Physiology, Volume 111, Issue 5, Page 2438-2448, 1 May 2026.Abstract Physiological interpretations of Systems Biology have made many advances since the Principles of Systems Biology were first published in this journal in 2008. Those advances show that the main principle, Biological Relativity, is a logical necessity since no system can exist without the form of the system.
Denis Noble, Reine Bourret
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Are physiological oscillations physiological?
The Journal of Physiology, Volume 604, Issue 9, Page 3672-3693, 1 May 2026.Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
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Quantum Time‐Marching Algorithms for Solving Linear Transport Problems Including Boundary Conditions
International Journal for Numerical Methods in Engineering, Volume 127, Issue 8, 30 April 2026.ABSTRACT This article presents the first complete application of a quantum time‐marching algorithm for simulating multidimensional linear transport phenomena with arbitrary boundaries, whereby the success probabilities are problem intrinsic. The method adapts the linear combination of unitaries algorithm to block encode the diffusive dynamics, while ...
Sergio Bengoechea +2 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.Schematic illustrating the mechanism by which the peptide Angio‐3 attenuates pulmonary fibrosis. Following lung injury, activation of the coagulation cascade via Factor Xa (FXa) signals through protease‐activated receptor‐1 (PAR‐1) to activate fibroblasts and promote fibrosis.
Dan Wang +9 more
wiley +1 more source