Results 41 to 50 of about 39,475 (232)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Singular standing-ring solutions of nonlinear partial differential equations

, 2009
We present a general framework for constructing singular solutions of nonlinear evolution equations that become singular on a d-dimensional sphere, where d>1. The asymptotic profile and blowup rate of these solutions are the same as those of solutions of
Bricmont, Budd, Budd, Ditkowsky, Fibich, Fibich, Fibich, Gadi Fibich, Galaktionov, Galaktionoy, Gavish, Giga, Giga, Grow, Guy Baruch, Herrero, Herrero, Herrero, Ilan, Matos, Merle, Merle, Nir Gavish, Raphael, Raphael, Ren, Sulem, Velaquez, Zaag, Zaag, Zaag   +30 more
core   +1 more source

Schrodinger Equation for Nanoscience

, 2003
3 ...
Marciak-Kozlowska, J., Kozlowski, M.
openaire   +2 more sources

Energy decay rate of multidimensional inhomogeneous Landau–Lifshitz–Gilbert equation and Schrödinger map equation on the sphere

Advances in Difference Equations, 2018
We consider the multidimensional dimensional inhomogeneous Landau–Lifshitz–Gilbert (ILLG) equation and its degenerate case, the Schrödinger map equation.
Penghong Zhong, Chao Zhang, Fengong Wu
doaj   +1 more source

Solving a nonlinear fractional Schrödinger equation using cubic B-splines

Advances in Difference Equations, 2020
We study the inhomogeneous nonlinear time-fractional Schrödinger equation for linear potential, where the order of fractional time derivative parameter α varies between 0 < α < 1 $0 < \alpha < 1$ .
M. Erfanian, H. Zeidabadi, M. Rashki, H. Borzouei   +3 more
doaj   +1 more source

Some Spectral Properties of Schrödinger Operators on Semi Axis

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2023
The main aim of this work is to investigate some spectral properties of Schrödinger operators on semi axis. We first present the Schrödinger equation with a piecewise continuous potential function q so that the problem differs from the classical ...
İbrahim Erdal
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source