Results 21 to 30 of about 282,906 (343)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Der Einfluss des Bildungsniveaus von Frauen auf das Scheidungsverhalten in der Schweiz, 1952–2013
Swiss Journal of Sociology, 2017 Der Beitrag zeigt auf, dass von 1952 bis 2003 in der Schweiz für hoch gebildete Frauen die höchste Scheidungswahrscheinlichkeit bestand. Von 2004 bis 2013 hingegen sind keine bildungsspezifischen Unterschiede hinsichtlich des Scheidungsverhaltens mehr ...
Villiger Simone
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Cognitio, 2021 Das Europäische Parlament und der Rat haben in der Richtlinie 2016/8001 weitreichende Verfahrensgarantien in Strafverfahren gegen Kinder und Jugendliche festgelegt. Damit konkretisieren sie die bereits bestehenden internationalen Standards.
Elvira Kolb
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The relationship between flexible and self-regulated learning in open and distance universities
International Review of Research in Open and Distributed Learning, 2012 Flexibility in learning provides a student room for volitional control and an array of strategies and encourages persistence in the face of difficulties.
Per Bernard Bergamin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Gender, 2022 Bis 1989 verweigerten die Genfer Behörden Sexarbeiterinnen ein Leumundszeugnis mit der Begründung, dass Prostitution einen besonders „unehrenhaften“ Charakter zum Ausdruck bringe.
Sarah Baumann
doaj +1 more source