Results 31 to 40 of about 89,270 (291)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Der Einfluss des Bildungsniveaus von Frauen auf das Scheidungsverhalten in der Schweiz, 1952–2013
Swiss Journal of Sociology, 2017 Der Beitrag zeigt auf, dass von 1952 bis 2003 in der Schweiz für hoch gebildete Frauen die höchste Scheidungswahrscheinlichkeit bestand. Von 2004 bis 2013 hingegen sind keine bildungsspezifischen Unterschiede hinsichtlich des Scheidungsverhaltens mehr ...
Villiger Simone
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The relationship between flexible and self-regulated learning in open and distance universities
International Review of Research in Open and Distributed Learning, 2012 Flexibility in learning provides a student room for volitional control and an array of strategies and encourages persistence in the face of difficulties.
Per Bernard Bergamin +3 more
doaj +1 more source
International Journal of Health Professions, 2022 Interprofessionelle Lehre (IPL) bedeutet, dass Studierende verschiedener Professionen mit-, von- und übereinander lernen. 2019 wurde im Kanton Zürich ein interprofessioneller Ausbildungstag (IPE-Tag) mit 68 Studierenden und acht Dozierenden über acht ...
Osterwalder Phylicia +5 more
doaj +1 more source
Vom gemessenen zum angemessenen Körper - Human Enhancement als historischer Prozess [PDF]
, 2012 An manchen Tagen sind Körper und Psyche in Bestform: Die Kommunikation gelingt eloquent, Konzentration und Ausdauer lassen ausgezeichnete Leistungen zu. Können pharmakologische Substanzen einem solchen Zustand auf die Sprünge helfen? Unter dem Stichwort «
Ritzmann, Iris; https://orcid.org/
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
»Genres sind austauschbare Gefäße«. Interview mit Ivan Engler
Zeitschrift für Fantastikforschung, 2021 Interview with Swiss filmmaker Ivan Engler.
Simon Spiegel
doaj +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source