Results 181 to 190 of about 65,822 (289)

RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Peripheral nerve injury‐induced muscle atrophy shares core pathophysiological features with systemic wasting disorders including cachexia and sarcopenia, yet early molecular triggers remain undefined. This study investigates the pathogenic role of receptor‐interacting protein kinase 3 (RIPK3) in denervation atrophy.
Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun   +6 more
wiley   +1 more source

Racial variations in sciatic nerve anatomy: A systematic review and meta-analysis. [PDF]

PLoS One
Abdu SM, Abdu H, Seid Muhaba E, Msaye Assefa E, Mankelkl G.   +4 more
europepmc   +1 more source

Things We Do for No Reason™: Prescribing gabapentinoids for pain

Journal of Hospital Medicine, Volume 21, Issue 6, Page 670-676, June 2026.
Visual Abstract Abstract Gabapentin and pregabalin are among the most frequently prescribed medications in the United States, with gabapentin in the top 10 and pregabalin in the top 100. Despite FDA approval for only select neuropathic conditions, most use is for off‐label pain indications.
Niti G. Patel, David Goese, Steven M. Belknap, Charles L. Madeira, Jeffrey H. Barsuk   +4 more
wiley   +1 more source

A Novel Surgical Approach to Induce an Ankle Joint Contracture in Rats

Journal of Orthopaedic Research, Volume 44, Issue 6, June 2026.
ABSTRACT Our primary aim was to establish a novel surgical immobilization approach to induce a persistent ankle plantar‐flexion contracture in the Wistar rat. A stainless steel suture was placed in experimental animals (n = 14) and pulled taut between the calcaneal bone and the knee joint, restricting dorsal‐flexion while still allowing for limited ...
Guido Geusebroek, Jaap van Dieën, Wendy Noort, Giovanni Ramdin, Han Houdijk, Huub Maas   +5 more
wiley   +1 more source

Delayed sciatic nerve palsy due to a subepineural hematoma following a gluteal gunshot injury: A case report. [PDF]

Trauma Case Rep
Assaf F, Saber A, Saad R, Sakhat G, Makhoul E.   +4 more
europepmc   +1 more source

Ultrasound‐Guided Peripheral Nerve Blocks for Percutaneous Treatments of Common Tendinopathies

Journal of Ultrasound in Medicine, Volume 45, Issue 6, Page 1139-1161, June 2026.
Objectives Ultrasound‐guided percutaneous needle fenestration (UPNF) and percutaneous needle tenotomy (UPNT) are minimally invasive procedures commonly used to treat chronic tendinopathies. However, these techniques can be painful, potentially limiting patient tolerance, satisfaction, and procedural feasibility. Although local anesthetics (LAs) provide
Tomás Ribeiro‐da‐Silva, Robert D. Pagan Rosado, Wesley Troyer, Matthew A. Cascio, Eva Kubrova, Sebastian Encalada, Nuno Ferreira‐Silva, Mark Friedrich B. Hurdle   +7 more
wiley   +1 more source

Optimizing sciatic nerve exposure: Insights from a multicenter experience and review of the literature. [PDF]

Brain Spine
Martínez-Benia F, Rodríguez-Aceves CA, Robla-Costales J, Garozzo D, Di Masi G, Moragues R, Socolovsky M.   +6 more
europepmc   +1 more source

Ultrasound-Guided Sural Nerve and Tibial Nerve Block Provides Comparable Analgesia to Popliteal Sciatic Nerve Block Following Calcaneal Surgery: A Single Center Randomized Controlled Double-Blind Study

Jun Yao,1,2,* Jialin Cai,2,* Qingwang Lu,2 Xiaojing Huang3 1Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, People’s Republic of China; 2Department of Anesthesiology, Jinjiang ...
Yao J, Huang X, Cai J, Lu Q
core  

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, Volume 2, Issue 2, Page 309-342, June 2026.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications

Small, Volume 22, Issue 33, 12 June 2026.
Particle shape is a key design parameter governing biological interactions. Advances in fabrication enable precise control over anisotropy and compartmentalization, allowing modulation of cellular uptake, transport, and biodistribution, ultimately enhancing therapeutic performance. ABSTRACT Polymer geometry is a primary determinant of physical behavior
Francisca G. Perfeito, Mariana B. Oliveira, João F. Mano   +2 more
wiley   +1 more source