Results 171 to 180 of about 66,046 (310)

Selective Small‐Molecule AdipoR1 Agonist 3‐Hydroxy Pterocarpan Salt (CDRI‐1709S) Ameliorates Skeletal Muscle Atrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy is a frequent comorbidity of metabolic disorders and chronic diseases, and despite its high prevalence, no pharmacological therapy is available, representing a major unmet clinical need. Adiponectin and its receptors are key regulators of skeletal muscle metabolism, mitochondrial function and myogenesis, yet ...
Md. Rameez Moin, Shyamal Pal, Shubhrajyoti Das, Pallavi Awasthi, Anushka Talukdar, Akhilesh Kumar, Shruti Suhas Varode, Nikhil Nikolas, Shamima Khatoon, Madhav Nilkanth Mugale, Rajdeep Guha, Sabyasachi Sanyal, Atul Goel   +12 more
wiley   +1 more source

Nerve growth factor (NGF) in the central nervous system [PDF]

, 1990
Bandtlow, Christine, Heumann, Rolf, Bjorklund, A., Meyer, Michael, Hengerer, Bastian, Lindholm, Dan, Aguayo, A., Ottoson, D., Spranger, Matthias, Thoenen, Hans   +9 more
core   +1 more source

Biodegradable, Biologically Safe Nanogenerators for Self‐Powered Bio‐Integrated Systems

Small Structures, Volume 7, Issue 8, August 2026.
Biodegradable TENGs, PENGs, and hybrid systems convert biomechanical motions into electrical signals while safely degrading after use. This review highlights their working mechanisms, biodegradable material platforms, and wearable and implantable bio‐integrated applications, including motion and respiration monitoring, biosignal detection, electrical ...
Sungkeun Han, Hye‐Min Lee, Won Bae Han, Venkata Ramesh Naganaboina, Hanjun Ryu, Suk-Won Hwang   +5 more
wiley   +1 more source

Uridine Improves Locomotor Activity and Sciatic Nerve Integrity in a Mouse Model of Diabetes Mellitus. [PDF]

Biomolecules
Țucă AM, Mitran SI, Burada E, Preda AN, Dan AO, Târtea EA, Greșiță A, Pană RC, Hădăreanu DR, Sfredel V, Târtea G.   +10 more
europepmc   +1 more source

Suspected multipartite patella in a Pomeranian dog successfully treated with osteochondral debridement, cerclage suture and transarticular external skeletal fixation

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract A 4‐year‐old, male, neutered Pomeranian presented with a 3‐week history of an acute‐onset Grade 3/5 left pelvic limb lameness, with no reported history of trauma. Radiographic and computed tomographic studies revealed separation of the left patella into multiple small variably sized, minimally displaced, bony fragments, with rounded margins. A
Charlotte Nix, Robert Dudley
wiley   +1 more source

Renal atrophy, bowel obstruction, and sciatic nerve impingement secondary to deep endometriosis. [PDF]

CMAJ
Singh SS, Duigenan S, Tanara L, Flaxman TE.   +3 more
europepmc   +1 more source

Pharmacological Inhibition of Cav2.2 Channels by Recombinant Phα1β Toxin (CTK01512‐2)

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
The recombinant Phα1β toxin (CTK01512‐2) partially and reversibly inhibits Cav2.2 calcium channels in HEK‐293 cells. CTK01512‐2 displays dose‐dependent inhibition of N‐type calcium currents, with an IC50 of 3.94 nM. In vivo, CTK01512‐2 effectively reduces mechanical allodynia in a neuropathic pain model, confirming its antinociceptive activity ...
Natália Virtude Carobin, Thamyris Reis Moraes, Luana Assis Ferreira, Christopher Kushmerick, Marcus Vinícius Gomez, Célio José Castro Junior   +5 more
wiley   +1 more source

A Case Report on Unclassified Anatomical Sciatic Nerve Variant in Acetabulum Fracture. [PDF]

J Orthop Case Rep
Bheemreddyvalla AR, Senthilrajan, Harisivanandan, Maligi VB, Chandak HD.   +4 more
europepmc   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, Volume 183, Issue 16, Page 5120-5147, August 2026.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Histological evaluation of fascicular damage following repeated sciatic nerve transfixion: an anatomical study. [PDF]

J Anesth Analg Crit Care
Boscolo-Berto R, De Cassai A, Contran M, Macchi V, Manzo V, De Caro R, Dost B, Tulgar S, Boscolo A, Navalesi P, Porzionato A.   +10 more
europepmc   +1 more source