Results 151 to 160 of about 30,589 (311)

Peri‐operative pain management in major lower extremity amputation in vascular Surgery: a UK anaesthetic and vascular surgery Delphi consensus study*

open access: yesAnaesthesia, Volume 81, Issue 5, Page 664-674, May 2026.
Summary Introduction Major lower extremity amputations occurring secondary to vascular disease remain prevalent worldwide. Pain surrounding these procedures is complex, multifactorial and associated with poor functional and psychosocial outcomes. The evidence base informing pain management approaches in major lower extremity amputations remain largely ...
Thanapon Ekkunagul   +81 more
wiley   +1 more source

A VARIATION IN THE HIGH DIVISION OF THE SCIATIC NERVE AND ITS RELATION WITH PIRIFORMIS MUSCLE

open access: yesNational Journal of Medical Research, 2011
The aim of the study was to describe and analyze sciatic nerve variation especially the higher division within the lesser pelvis and its different routes of exit from pelvis.
Shailesh Patel   +4 more
doaj  

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2307-2323, May 2026.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert   +13 more
wiley   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2324-2340, May 2026.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann   +12 more
wiley   +1 more source

Ionic‐Electronic Hydrogel‐Liquid Metal Composite Bilayer with Tissue‐Adaptive and Adhesive Properties for Closed‐Loop Neuroprosthetic System

open access: yesAdvanced Functional Materials, Volume 36, Issue 31, 16 April 2026.
A hydrogel–liquid metal composite peripheral nerve interface (HLB‐PNI) combines electrically durable electrodes and tissue‐adhesive hydrogel for tissue‐adaptive implantation. In nerve‐injured rats, it enables the diagnosis of sensory‐motor connectivity via stimulation and neural signal recording.
Yewon Kim   +5 more
wiley   +1 more source

Biomaterials‐Based Hydrogel with Superior Bio‐Mimetic Ionic Conductivity and Tissue‐Matching Softness for Bioelectronics

open access: yesAdvanced Functional Materials, Volume 36, Issue 30, 13 April 2026.
By mimicking the ion‐accelerating effect of ion channel receptors in neuron membranes, a biomaterials‐based ionic hydrogel (BIH) is developed, which offers a high ionic conductivity of 7.04 S m−1, outperforming conventional chitosan, cellulose, agarose, starch, and gelatin based ionic hydrogels.
Baojin Chen   +7 more
wiley   +1 more source

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