Results 181 to 190 of about 30,589 (311)

Activation of GPR35 in the Anterior Cingulate Cortex Alleviates Neuropathic Pain and Depression‐Related Behavior

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Sciatic nerve injury led to a significant increase in the expression of GPR35 in the ACC region of mice. This increased interaction with Nr4a1 can activate the PI3K/AKT signaling pathway, thereby reducing neuroinflammation and playing a role in alleviating hyperalgesia and depressive behavior in mice. ACC, anterior cingulate cortex.
Jianling Xu   +9 more
wiley   +1 more source

The Small Molecule Compound Eupalinolide B Ameliorates Depressive Behaviors and Neuropathic Pain in Mice With Spared Nerve Injury: Integrating Network Pharmacology, Molecular Docking, Bioinformatics, Molecular Dynamics Simulation and Experimental Verification

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Through network pharmacology, molecular docking, molecular dynamics simulations, and bioinformatics techniques, three potential core targets of EB for the treatment of pain‐depression comorbidity (EGFR, PTGS2, and JUN) were identified. Subsequent animal studies demonstrated that EB alleviates pain and depression‐like behaviors by inhibiting glial cell ...
Xuesong Yang   +4 more
wiley   +1 more source

Popliteal sciatic nerve block for high-risk patients undergoing lower limb angioplasty: A prospective double-blinded randomized controlled trial. [PDF]

open access: yesMedicine (Baltimore), 2023
Noikham A   +5 more
europepmc   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management

open access: yesEuropean Journal of Pain, Volume 30, Issue 4, April 2026.
ABSTRACT Background and Objective Fatty acid‐binding proteins (FABPs) are intracellular lipid transporters. Pharmacological inhibition of FABP5 is analgesic in preclinical visceral, inflammatory, neuropathic and joint pain models. Genetic knockout or knockdown of FABP5 induces analgesia in select visceral and inflammatory pain models.
William Warren   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy