Results 91 to 100 of about 23,100 (268)

Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats

Journal of Pharmacological Sciences, 2015
Bortezomib, an effective anticancer drug for multiple myeloma, often causes peripheral neuropathy which is mainly characterized by numbness and painful paresthesia.
Shota Yamamoto, Takehiro Kawashiri, Hitomi Higuchi, Kuniaki Tsutsumi, Soichiro Ushio, Takanori Kaname, Masafumi Shirahama, Nobuaki Egashira   +7 more
doaj   +1 more source

Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation. [PDF]

, 2018
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and dose-limiting side effect of cancer treatment that affects millions of cancer survivors throughout the world and current treatment options are extremely limited by their side effects ...
Mackie, Ken, Marty, Vincent N, Mulpuri, Yatendra, Munier, Joseph J, Schmidt, Brian L, Seltzman, Herbert H, Spigelman, Igor   +6 more
core   +1 more source

Effect of pre-germinated brown rice intake on diabetic neuropathy in streptozotocin-induced diabetic rats [PDF]

, 2007
Background To study the effects of a pre-germinated brown rice diet (PR) on diabetic neuropathy in streptozotocin (STZ)-induced diabetic rats. Methods The effects of a PR diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and ...
Seigo Usuki, Yukihiko Ito, Keiko Morikawa, Mitsuo Kise, Toshio Ariga, Michael Rivner, Robert K Yu   +6 more
core   +2 more sources

Prostaglandin D2 Synthase Controls Schwann Cells Metabolism and Peripheral Myelin Homeostasis

Glia, Volume 74, Issue 3, March 2026.
Prostaglandin D2 Synthase (L‐PGDS) controls PPNS myelin lipids’ composition and Schwann cells energetic metabolism In the absence of L‐PGDS Schwann cells turn to acetate as the main energetic source. These metabolic changes result in ketone bodies production to preserve neuronal survival.
Amelia Trimarco, Matteo Audano, Rosa La Marca, Marta Pellegatta, Paolo Canevazzi, Mariaconcetta Cariello, Marta Falco, Silvia Pedretti, Gabriele Imperato, Alessandro Cestaro, Paola Podini, Giorgia Dina, Angelo Quattrini, Luca Massimino, Donatella Caruso, Nico Mitro, Carla Taveggia   +16 more
wiley   +1 more source

The role of thrombin in the pathogenesis of diabetic neuropathy.

PLoS ONE, 2019
Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombin in
Efrat Shavit-Stein, Ramona Aronovich, Constantin Sylantiev, Shany Guly Gofrit, Joab Chapman, Amir Dori   +5 more
doaj   +1 more source

Nanoparticles‐Mediated Modulation of TRP Channels: Advances and Therapeutic Potential

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Karina A. Foster, Noy Midler, Ori Shine, Dekel Rosenfeld   +3 more
wiley   +1 more source

Cryoglobulinaemic neuropathy: a further cause of bilateral sciatic neuropathy

International Archives of Medicine, 2008
Bilateral sciatic neuropathy is a rare condition and it has been described as a compression or entrapment neuropathy but it is an uncommon clinical manifestation due to necrotizing vasculitis. We report an unusual case of cryoglobulinaemic neuropathy in an elderly woman with no underlying infectious or neoplastic cause; acute bilateral sciatic ...
Pérez, Desireé, de la Torre, Ricardo, Carrio, Isabel, Pinto, Jesús, Morís, Germán   +4 more
openaire   +2 more sources

Non‐Pulmonary Mechanisms of Action of Ambroxol in In Vivo Experimental Models: a Systematic Review

Fundamental &Clinical Pharmacology, Volume 40, Issue 2, March 2026.
ABSTRACT Background Repositioning offers a cost‐effective approach to discovering new therapeutic applications for existing medications. Ambroxol, primarily used as a mucolytic for respiratory diseases, has demonstrated anti‐inflammatory, analgesic, and antioxidant properties, suggesting potential benefits in non‐pulmonary conditions.
Michelline Joana Tenório Albuquerque Madruga Mesquita, Anne Caroline Silva Nogueira da Cruz, Rafael de Abreu Lima, Joana Tenório‐Meireles, Arney José Nogueira Farias, Isabela Nogueira Santos, Gustavo Frota, Taciana Gabrielle Pinheiro de Moura Carvalho, Rafael Antônio Freire Carvalho, Jorge Antônio Meireles‐Teixeira, Tereza Prazeres, Rafael Cardoso Carvalho, Maria do Socorro de Sousa Cartágenes, João Batista Santos Garcia   +13 more
wiley   +1 more source

Effects of decompression on behavioral, electrophysiologic, and histomorphologic recovery in a chronic sciatic nerve compression model of streptozotocin-induced diabetic rats

Journal of Pain Research, 2017
Ping-Hui Wang,1 Cheng-Chang Yang,2 Wei-Ren Su,3 Po-Ting Wu,3 Shun-Chien Cheng,1 I-Ming Jou4 1Department of Orthopedics, Chi-Mei Medical Center, 2Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 3Department of ...
Wang PH, Yang CC, Su WR, Wu PT, Cheng SC, Jou IM   +5 more
doaj  

Profound Neuropathy after Penetrating Transection of the Sciatic Nerve by Femoral Cerclage Wire: Illustrative Case and Management Strategy

Neurotrauma Reports
Sciatic nerve injury associated with total hip arthroplasty (THA) confers chronic and progressive disability. Mechanisms of injury are heterogeneous and management nuances are often case-specific.
John K. Yue, Jun Yeop Oh, Alexander A. Aabedi, Jia-Shu Chen, Kenneth X. Probst, Vinil N. Shah, Rosanna L. Wustrack, Line G. Jacques   +7 more
doaj   +1 more source