Results 81 to 90 of about 144,018 (191)

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, Volume 100, Issue 4, Page 709-736, October 2026.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Long-Term Treatment With Ranirestat (AS-3201), a Potent Aldose Reductase Inhibitor, Suppresses Diabetic Neuropathy and Cataract Formation in Rats

Journal of Pharmacological Sciences, 2008
We investigated the chronic functional and histopathological changes in the sciatic nerve and lens of streptozotocin (STZ)-diabetic rats and evaluated the preventive effects of ranirestat (AS-3201), a potent aldose reductase inhibitor, on these changes ...
Takafumi Matsumoto, Yoshiyuki Ono, Akemi Kuromiya, Kaoru Toyosawa, Yoshinaka Ueda, Vera Bril   +5 more
doaj   +1 more source

Cerebrolysin improves sciatic nerve dysfunction in a mouse model of diabetic peripheral neuropathy

Neural Regeneration Research, 2016
To examine the effects of Cerebrolysin on the treatment of diabetic peripheral neuropathy, we first established a mouse model of type 2 diabetes mellitus by administering a high-glucose, high-fat diet and a single intraperitoneal injection of ...
Han-yu Dong, Xin-mei Jiang, Chun-bo Niu, Lin Du, Jun-yan Feng, Fei-yong Jia   +5 more
doaj   +1 more source

Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hindlimbs of Chronic Hypoglycaemic Rats

, 2017
Peripheral neuropathy is one of the most common complications of diabetic hyperglycaemia. Insulin-induced hypoglycaemia (IIH) might potentially exacerbate or contribute to neuropathy as hypoglycaemia also causes peripheral neuropathy.
Soeborg, Henrik, Henrik Soeborg, Jette Nowak, Melissa Chapman, Jens Lykkesfeldt, Jensen, Vivi F.H., Lykkesfeldt, Jens, Ingrid B. Bogh, Chapman, Melissa, Vivi F. H. Jensen, Molck, Anne Marie, Anne-Marie Molck, Nowak, Jette, Bogh, Ingrid B.   +13 more
core   +1 more source

Nutritional optic and peripheral neuropathy: a case report. [PDF]

, 2009
INTRODUCTION: The link between nutritional status and either optic or peripheral neuropathies is well established with tobacco, ethanol, deficiencies in thiamine, vitamin A, B12, B3 and B6 and protein-energy malnutrition all being causative.
Nightingale, LM, Laura M Nightingale, Paviour, DC, Dominic C Paviour   +3 more
core   +1 more source

Effects of decompression on behavioral, electrophysiologic, and histomorphologic recovery in a chronic sciatic nerve compression model of streptozotocin-induced diabetic rats

Journal of Pain Research, 2017
Ping-Hui Wang,1 Cheng-Chang Yang,2 Wei-Ren Su,3 Po-Ting Wu,3 Shun-Chien Cheng,1 I-Ming Jou4 1Department of Orthopedics, Chi-Mei Medical Center, 2Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 3Department of ...
Wang PH, Yang CC, Su WR, Wu PT, Cheng SC, Jou IM   +5 more
doaj  

Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination

, 2018
OBJECTIVE: Sciatic nerve neuropathy can be observed following intramuscular gluteal injections. The histopathological examination of sciatic nerve damage following intramuscular injection in the gluteal region for acute pain treatment is not feasible in ...
Altuner, Dudu, bostan, Habib, ERKUT, Adem, KANAT, Ayhan, Kocer, Abdulkadir, CABALAR, Murat, KALKAN, Yildiray, Altinay, Serdar, BALIK, Sabri, Salihoglu, Ziya, TUMKAYA, Levent, Balık, Sabri, Altınay, Serdar, Kalkan, Yıldıray   +13 more
core   +1 more source

A case of sciatic neuropathy after caesarean section under spinal anaesthesia

, 2006
We present a rare case in which a healthy parturient developed a left sciatic neuropathy after spinal anaesthesia for caesarean section. Intraoperatively, a wedge was placed under her right buttock to tilt the pelvis and uterus to the left, to minimise ...
Karabeyoglu, I., Postaci, A., Erdogan, G., Turan, O., DİKMEN, BAYAZİT, Erdogan, GÜLAY, I. Karabeyoglu, O. Turan, B. Dikmen, G. Erdogan, A. Postaci   +10 more
core   +1 more source

The role of thrombin in the pathogenesis of diabetic neuropathy.

PLoS ONE, 2019
Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombin in
Efrat Shavit-Stein, Ramona Aronovich, Constantin Sylantiev, Shany Guly Gofrit, Joab Chapman, Amir Dori   +5 more
doaj   +1 more source

Sciatic neuropathies. [PDF]

BMJ, 1983
J D, Stewart, E, Angus, D, Gendron
openaire   +2 more sources