Results 61 to 70 of about 144,018 (191)

Pro-inflammatory cytokines and leukocyte integrins associated with chronic neuropathic pain in traumatic and inflammatory neuropathies: Initial observations and hypotheses

Frontiers in Immunology, 2022
Leukocyte infiltration and persistence within peripheral nerves have been implicated in chronic nociception pathogenesis in murine peripheral neuropathy models.
Chaoling Dong, Eroboghene E. Ubogu
doaj   +1 more source

Infiltration between the popliteal artery and the capsule of the knee (IPACK) vs. selective tibial nerve block for analgesia after total knee arthroplasty: a triple‐blinded randomised controlled trial

Anaesthesia, EarlyView.
Summary Introduction Infiltration between the popliteal artery and the capsule of the knee (IPACK) and the selective tibial nerve block provide analgesia for the posterior aspect of the knee after total knee arthroplasty. This randomised controlled triple‐blinded trial tested the hypothesis that IPACK provides superior analgesia to selective tibial ...
Marta Szyszko, Julien Wegrzyn, Jean‐Benoit Rossel, Alexandre Koninckx, Marine Pirot, Eric Albrecht   +5 more
wiley   +1 more source

Profound Neuropathy after Penetrating Transection of the Sciatic Nerve by Femoral Cerclage Wire: Illustrative Case and Management Strategy

Neurotrauma Reports
Sciatic nerve injury associated with total hip arthroplasty (THA) confers chronic and progressive disability. Mechanisms of injury are heterogeneous and management nuances are often case-specific.
John K. Yue, Jun Yeop Oh, Alexander A. Aabedi, Jia-Shu Chen, Kenneth X. Probst, Vinil N. Shah, Rosanna L. Wustrack, Line G. Jacques   +7 more
doaj   +1 more source

Peripheral regeneration of Aβ low‐threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways

The Journal of Physiology, EarlyView.
Abstract figure legend The regeneration of Aβ low‐threshold mechanoreceptors (Aβ‐LTMRs), sensory neurons responsible for discriminative touch, has not previously been explored. Here, we took advantage of the selective expression of Calb1 in Aβ‐LTMRs to generate two genetic mouse models for studying their regenerative response after nerve injury.
Sara Bolívar, Natàlia Martínez‐Mateu, David Ovelleiro, Esther Udina   +3 more
wiley   +1 more source

Schwann cell-derived exosomes ameliorate peripheral neuropathy induced by ablation of dicer in Schwann cells

Frontiers in Cellular Neuroscience
BackgroundMicroRNAs (miRNAs) in Schwann cells (SCs) mediate peripheral nerve function. Ablating Dicer, a key gene in miRNA biogenesis, in SCs causes peripheral neuropathy.
Lei Wang, XueRong Lu, Alexandra Szalad, Xian Shuang Liu, Yi Zhang, Xinli Wang, William Anthony Golembieski, Brianna Powell, Mikkala Mccann, Mei Lu, Michael Chopp, Michael Chopp, Zheng Gang Zhang   +12 more
doaj   +1 more source

Cryoglobulinaemic neuropathy: a further cause of bilateral sciatic neuropathy

International Archives of Medicine, 2008
Bilateral sciatic neuropathy is a rare condition and it has been described as a compression or entrapment neuropathy but it is an uncommon clinical manifestation due to necrotizing vasculitis. We report an unusual case of cryoglobulinaemic neuropathy in an elderly woman with no underlying infectious or neoplastic cause; acute bilateral sciatic ...
Pérez, Desireé, de la Torre, Ricardo, Carrio, Isabel, Pinto, Jesús, Morís, Germán   +4 more
openaire   +2 more sources

AN UNUSUAL CAUSE OF SCIATIC PAIN

, 2001
We describe a 47-year-old woman with sciatic neuropathy caused by compression of the sacral plexus by posterior shift of the uterus.
M. Murakami, H. Moriya, K. Takahashi, Y. Murata   +3 more
core   +1 more source

Schwann Cell‐Specific ATG7‐Dependent Autophagy Protects Myelin in a Mouse Model of Krabbe Disease

Glia, Volume 74, Issue 12, December 2026.
Krabbe disease (KD) is caused by mutations in GALC and deregulated lysosomal function in Schwann cells (SCs). Using a SC‐specific Galc‐cKO mouse, we identified altered autophagy in SCs during KD progression. Further ablation of Atg7 in SCs of KD worsened disease severity.
Narayan Dhimal, Aditya Sidharth, Jiajun Zhang, Trina Rudra, Edward Hurley, Pablo M. Paez, Fraser J. Sim, Daesung Shin, M. Laura Feltri   +8 more
wiley   +1 more source

Characterization of the Lysophosphatidic Acid Receptor 5 Antagonist RLPA‐76 as a Novel Analgesic in Male Rats and Mice

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Clinically used analgesics such as gabapentinoids and opioids have limited efficacy and adverse effects like abuse liability, and there is a dire need for novel analgesics with improved safety profiles. Since lysophosphatidic acid can induce neuropathic pain in rodents, LPA receptor antagonists have been investigated as potential analgesics ...
Kristen L. Woodhouse, Maowei Wang, Sai Ganesh Balaji Venkata Anupindi, Olatunbosun Adeoke, Dehui Zhang, Yanan Zhang, Jun‐Xu Li   +6 more
wiley   +1 more source

The Effect of Co-administration of 4-Methylcatechol and Progesterone on Sciatic Nerve Function and Neurohistological Alterations in Streptozotocin-Induced Diabetic Neuropathy in Rats [PDF]

Cell Journal, 2011
Objective: Diabetic neuropathy is the most common complication of diabetes mellitusaffecting the nervous system. In this study, we investigated the in vivo effects of combinedadministration of 4-methylcatechol (4-MC) and progesterone (P) as a ...
Marzieh Panahi, Hamidreza Sameni
doaj