Results 51 to 60 of about 144,018 (191)

The correlation between insulin and OCT-6 transcription factor in Schwann cells and sciatic nerve of diabetic rats

Genes and Diseases, 2018
Insulin signal is one of the vital signaling cascade required for Schwann cells to myelinate the axons of peripheral nervous system (PNS). Myelin formation of peripheral nerve is a complex molecular event controlled by different neurotrophic and ...
Mallahalli S. Manu, Kuruvanthe S. Rachana, Gopal M. Advirao   +2 more
doaj   +1 more source

The effect of different designs of custom foot orthoses on pain and balance in individuals with plantar fasciitis: A randomized controlled trial with 6‐month follow‐up

PM&R, EarlyView.
Abstract Background Plantar fasciitis (PF) is a common cause of heel pain that significantly affects daily activities. Although custom foot orthoses (CFOs) are widely used to treat this condition, there is limited evidence comparing different orthotic designs and their effects on balance parameters.
Thanyachat Thanajiravipat, Jim Richards, Pichaya Hengsomboon, Ninwisan Hengsomboon, Sunee Bovonsunthonchai, Prasert Sakulsriprasert, Pavinee Harutaichun   +6 more
wiley   +1 more source

Toll‐Like Receptor 4 Signaling in Natural N‐Acylethanolamines and Derivative NAE‐Like Compounds: Mechanisms and Implications for Neuroimmune and Inflammatory Processes in a Systematic Search Approach

Phytotherapy Research, EarlyView.
ABSTRACT N‐acylethanolamines (NAEs) are endogenous fatty acid amides structurally related to the endocannabinoid anandamide and function as bioactive lipid mediators with broad regulatory roles in inflammation and neuroinflammation. Among pattern‐recognition receptors, Toll‐like receptor 4 (TLR4) occupies a central position in innate immune ...
Damiana Scuteri, Francesca Guida, Giacinto Bagetta, Sabatino Maione, Maria Tiziana Corasaniti, Morena Zusso   +5 more
wiley   +1 more source

Is resistance to ischaemia of motor axons in diabetic subjects due to membrane depolarization? [PDF]

, 1990
The reasons for the resistance to ischaemia of peripheral nerves in diabetics are not well understood. We have now explored whether axonal depolarization underlies this phenomenon, as has previously been proposed.
Weigl, Paul, Piwernetz, Klaus, Strupp, Michael, Bostock, Hugh, Grafe, Peter, Renner, Rolf   +5 more
core   +1 more source

Neuropathy - pain damage and the diabetic foot [PDF]

, 2008
Neuropathy, or the impairment of nerve structures and function, is a common complication in diabetes and affects up to one-third of patients. The most common manifestation is the loss of pain sensation and this can lead to unrecognised trauma injuries ...
Newton, Veronica
core   +4 more sources

Urolithin A Modulates SIRT‐1 Mediated Improvement of Mitochondrial Health in Experimental Model of Oxaliplatin Induced Peripheral Neuropathy

Phytotherapy Research, EarlyView.
ABSTRACT Oxaliplatin‐induced peripheral neuropathy (OIPN) is a major dose‐limiting adverse reaction of chemotherapy. It is characterised by motor and sensory hypersensitivity, loss of myelinated nerve fibres, oxidative stress, mitochondrial dysfunction and neuroinflammation.
Anubroto Pal, Sayani Banerjee, Lokesh Sharan, Ravindra Kumar, Neelanjan Chowdhury, Arka Das, S Sarath Babu, David Paul, Sugato Banerjee   +8 more
wiley   +1 more source

N-acetyl-L-cysteine mitigates diabetes-induced impairments in sciatic nerve

IBRO Neuroscience Reports
Diabetic neuropathy is a consequence of long-term hyperglycemia. The emergence of neuronal condition is a result of hyperglycemia-induced oxidative stress.
Sukhdev S. Kamboj, Satya P. Sharma, Wael M.Y. Mohamed, Rajat Sandhir   +3 more
doaj   +1 more source

Infiltration between the popliteal artery and the capsule of the knee (IPACK) vs. selective tibial nerve block for analgesia after anterior cruciate ligament reconstruction: a randomised controlled trial

Anaesthesia, EarlyView.
Summary Introduction Infiltration between the popliteal artery and the capsule of the knee (IPACK) and the selective tibial nerve block both provide analgesia for the posterior aspect of the knee after anterior cruciate ligament reconstruction. This randomised controlled triple‐blinded trial tested the hypothesis that IPACK provides superior analgesia ...
Ludovic Beun, Robin Martin, Trieu Hoai Nam Ngo, Jean‐Benoit Rossel, Matthieu André, Eric Albrecht   +5 more
wiley   +1 more source

Mitochondrial and bioenergetic dysfunction in trauma-induced painful peripheral neuropathy [PDF]

, 2015
Mitochondrial dysfunction is observed in various neuropathic pain phenotypes, such as chemotherapy induced neuropathy, diabetic neuropathy, HIV-associated neuropathy, and in Charcot-Marie-Tooth neuropathy. To investigate whether mitochondrial dysfunction
Lim, Tony K. Y., Lee, Seunghwan, Zhang, Ji, Rone, Malena B., Antel, Jack P., Malena B. Rone, Seunghwan Lee, Tony K. Y. Lim, Jack P. Antel, Ji Zhang   +9 more
core   +1 more source

Montelukast reduced docetaxel-induced peripheral neuropathy in rats by altering oxidative stress, histopathological damage, and gene expressions [PDF]

Brazilian Journal of Medical and Biological Research
Peripheral neuropathy (PN) is a common side effect of docetaxel (DTX). In this study, we aimed to evaluate the effects of montelukast (MNT), a leukotriene receptor antagonist drug, against DTX-induced PN in rats.
M.D. Karakoç, Ö. Özmen, M.N. Zengin, O. Çiftçi   +3 more
doaj   +1 more source