Results 101 to 110 of about 25,360 (296)
Advanced Science, EarlyView.In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen +12 more
wiley +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source
Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
wiley +1 more source
Conservative management for patients with sciatica: a systematic review [PDF]
, 2019 Background: Sciatica is a broad term describing spinally referred pain of neural origin that radiates into the leg. Sciatica is a significant burden to healthcare and health economies globally.
Cairns, Mindy +4 more
core +3 more sources
Sciatica due to extrapelvic heterotopic ossification: A case report [PDF]
, 2008 Introduction Sciatica is a common problem, usually caused by disc herniation or spinal stenosis. Low back pain is also present in most cases. When sciatica is the unique clinical finding, especially in young patients, extraspinal pathology should be ...
Spyros A Syggelos +10 more
core +2 more sources
Biomimetic 3D Tactile Sensor System With Neuromorphic Encoding for Fascicle‐Level Feedback
Advanced Intelligent Systems, EarlyView.A 3D biomimetic tactile sensor system converts skin‐like mechanical interactions into neural stimulation‐ready spike patterns. Embedded slow‐ and fast‐adapting sensors distinguish sustained pressure from transient touch, while neuromorphic encoding preserves their temporal signatures.
Minseok Kim +4 more
wiley +1 more source
Global Spine Journal, 2014 Introduction Elevated body mass index (BMI) or overweight and obesity are pandemics. Lumbar disc herniation and sciatica occur in every population and present severe socioeconomic consequences.
D. Samartzis +3 more
doaj +1 more source