Advanced Science, Volume 12, Issue 41, November 6, 2025.Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser +11 more
wiley +1 more source
Circulating T-Cell Receptor Excision Circles at Birth and Risk of Childhood Cancers. [PDF]
Cancers (Basel)Tao J +4 more
europepmc +1 more source
In Vitro Monitoring of Babesia microti Infection Dynamics in Whole Blood Microenvironments
Advanced Science, Volume 12, Issue 41, November 6, 2025.Here, an open microfluidic platform termed “µ‐Blood” is reported for real‐time, continuous monitoring of Babesia microti infection dynamics in vitro. µ‐Blood allows direct interrogation of whole blood with preserved integrity of the original whole blood microenvironment through an extended period (e.g., 72 h with mouse red blood cells) ex vivo. µ‐Blood
Chao Li +4 more
wiley +1 more source
Activity of combinations of bactericidal and bacteriostatic compounds in <i>Mycobacterium abscessus</i>-infected mice: an overview. [PDF]
Front MicrobiolLanni A +4 more
europepmc +1 more source
Paediatric rare diseases: Can large language models assist off‐label prescribing?
British Journal of Clinical Pharmacology, Volume 91, Issue 11, Page 3201-3212, November 2025.Aims To evaluate the effectiveness and reliability of large language models (LLMs) in retrieving and synthesizing biomedical information to support off‐label drug prescribing in paediatric rare diseases, and to compare their performance with human‐authored references in terms of scientific rationale, adverse events and drug interactions.
Anna Flamigni +3 more
wiley +1 more source
Cost-effectiveness of newborn screening for severe combined immunodeficiency: a systematic review. [PDF]
Clin Exp PediatrRana R, Afroz Keramat S, Ahmed M.
europepmc +1 more source
Parent and Child Influences on Adrenocortical Synchrony During Middle Childhood
Developmental Psychobiology, Volume 67, Issue 6, November 2025.ABSTRACT Parent–child synchrony, or coordination of behavioral, affective, and physiological responding during dyadic interactions, is associated with numerous positive child outcomes. Research considering how parental psychopathology influences synchrony, however, has failed to assess cooccurring parenting behaviors and styles that may influence ...
Sarah R. Black +4 more
wiley +1 more source
Rheumatologic and Autoimmune Features of Inborn Errors of Immunity: Implications for Diagnosis and Management. [PDF]
J Hum ImmunTobin JM, Cooper MA.
europepmc +1 more source
European Eating Disorders Review, Volume 33, Issue 6, Page 1246-1254, November 2025.ABSTRACT Objective Altered reward processing is proposed to be central to the pathology of anorexia nervosa (AN). This study aimed to investigate how aspects of reward dysfunction relate to suicidal thoughts and behaviours (STBs) in AN. Method We compared responses on self‐report measures of general (i.e., anticipatory, consummatory, and social reward)
Soo‐Eun Lee +2 more
wiley +1 more source
Impaired synaptic transmission and long-term potentiation in severe combined immunodeficient (SCID) mice. [PDF]
NeuroreportLupacchini L +4 more
europepmc +1 more source