Results 121 to 130 of about 858,677 (313)
, 2012 Recently, the interest in ensuring integration between science and mathematics has been increasing. Taking this interest into consideration, this paper investigates whether or not a programme integrating particular attainments of science and technology ...
Kaptan, Fitnat, Kiray, S. Ahmet
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Scientific argumentation is described as "a social process in which students build, question, and critique claims using evidence about the natural world." The Argumentation Toolkit curates resources meant to assist middle-school educators in ...
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
ARE BASIC SCIENCE AND BIOTECHNOLOGY COMPLEMENTARY ACTIVITIES?
Enhancing agricultural productivity depends greatly on the management of information flows between basic and applied research. A framework is developed to examine the mutual relationship between molecular biological research and agricultural ...
Buccola, Steven T., Xia, Yin
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Introduction to Alternative and Renewable Energy: Basic Energy Science
, 2011 This module is intended for use in a college-level introductory course in alternative and renewable energy. The document covers basic engineering science for understanding energy.
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Novel virulence-related genes that contribute to clinical infections of Salmonella enteritidis
202505 bcrcVersion of RecordRGCOthersNational Natural Science Fund in China under the Guangdong Major Project of Basic and Applied Basic Research ...
Sheng Chen +9 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source