Results 111 to 120 of about 23,783,860 (357)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Logic Column 18: Alternative Logics: A Book Review [PDF]
arXiv, 2007 This article discusses two books on the topic of alternative logics in science: "Deviant Logic", by Susan Haack, and "Alternative Logics: Do Sciences Need Them?", edited by Paul Weingartner.
arxiv
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Mathematical Logic in Computer Science [PDF]
arXiv, 2018 The article retraces major events and milestones in the mutual influences between mathematical logic and computer science since the 1950s.
arxiv
Annual Meeting of the American Political Science Association [PDF]
, 1927 J. R. Hayden
openalex +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
A framework for understanding data science [PDF]
arXivThe objective of this research is to provide a framework with which the data science community can understand, define, and develop data science as a field of inquiry. The framework is based on the classical reference framework (axiology, ontology, epistemology, methodology) used for 200 years to define knowledge discovery paradigms and disciplines in ...
arxiv