Results 151 to 160 of about 38,172,992 (295)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Arts and Science; Spring 2009

open access: yes, 2009
ARTS AND SCIENCE is published by the College of Arts and Science at Vanderbilt University in cooperation with the Office of Development and Alumni Relations Communications.Vanderbilt University.
Vanderbilt University. College of Arts and Science
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Arts and Science; Fall 2010

open access: yes, 2010
ARTS AND SCIENCE is published by the College of Arts and Science at Vanderbilt University in cooperation with the Office of Development and Alumni Relations Communications.Vanderbilt University.
Vanderbilt University. College of Arts and Science
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Arts and Science; Spring 2012

open access: yes, 2012
ARTS AND SCIENCE is published by the College of Arts and Science at Vanderbilt University in cooperation with the Office of Development and Alumni Relations Communications.Vanderbilt University.
Vanderbilt University. College of Arts and Science
core  

Home - About - Disclaimer - Privacy