Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2008 ARTS AND SCIENCE is published by the College of Arts and Science at Vanderbilt University in cooperation with the Office of Development and Alumni Relations Communications.Vanderbilt University.
Vanderbilt University. College of Arts and Science
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2008 ARTS AND SCIENCE is published by the College of Arts and Science at Vanderbilt University in cooperation with the Office of Development and Alumni Relations Communications.Vanderbilt University.
Vanderbilt University. College of Arts and Science
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Proceedings of the Arizona-Nevada Academy of Science, Volume 15 (1980)
, 1980 Twenty-Fourth Annual Meeting of the Arizona-Nevada Academy of Science and the Fifty-Sixth Annual Meeting Southwestern and Rocky Mountain Division American Association for the Advancement of Science / April 9-12, 1980 / Participating Societies: Arizona ...
Arizona-Nevada Academy of Science
core
The mediating effect of neuroticism on the association between brain signal variability in the prefrontal cortex and depression among healthy individuals. [PDF]
Brain Imaging BehavLu F +13 more
europepmc +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Proceedings of the Arizona-Nevada Academy of Science, Volume 05 (1969)
, 1969 THIRTEENTH ANNUAL MEETING / April 18-19, 1969 / Joint Meeting with the Arizona Academy of Science, Psi Chi National Honor Society in Psychology, National Science Teachers Association, Society of American Foresters, and Southwestern Interagency Fire ...
Arizona-Nevada Academy of Science
core
To Whom National Culture Matters: An Analysis of Mentions of Countries in Titles and Abstracts in Social and Personality Psychology and Related Fields From 1990 to 2020. [PDF]
Int J Psycholde Almeida I +4 more
europepmc +1 more source