Results 161 to 170 of about 6,304,582 (340)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Technology and Ageing—Theoretical Propositions from Science and Technology Studies (STS)

, 2019
In this chapter, I explore new grounds for theorizing ageing and digital technology. I do so by summarizing insights from critical studies of science and technology, i.e. the field of Science and Technology Studies (STS), in relation to ageing. The discussion revolves around three major insights that can be derived from the STS literature on ageing and
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The Sociotechnical in Digital Sociology: Methodological Possibilities and Limitations

Социология власти
Depending on the disciplinary direction and the scale of technological diffusion that was relevant at the time, the study of human-computer interaction has been characterized by various concepts.
Liliia V. Zemnukhova
doaj  

Study on AI Technology Empowerment of Smart Farms from the Perspective of Science Communication: A Case Study of Primary and Secondary School Students and Science and Technology Counselor

Yafang Liu
openalex   +2 more sources

Expertise in Political Contexts: Latour Avec the Third Wave in Science and Technology Studies

, 2020
David S. Caudill
openalex   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Integrating 4E cognition with science and technology studies: a framework for understanding AI applications. [PDF]

Front Artif Intell
Gahrn-Andersen R.
europepmc   +1 more source

Review Essay: Das "Politische" in den Science & Technology Studies. Eine Replik auf: Niklas Alexander Chimirri (2012). Review: Michalis Kontopodis & Jörg Niewöhner (Hrsg.) (2010). Das Selbst als Netzwerk

, 2012
Michalis Kontopodis
openalex   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source