TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo+11 more
wiley +1 more source
Advances in structural science: Education, outreach, and research applications. [PDF]
Bou-Nader C+12 more
europepmc +1 more source
Program of council for elementary science international. In collaboration with the association for childhood education international. Hotel Jefferson, St. Louis, Missouri. April 3, 1959 [PDF]
Willard Jacobson, L. J. Carr
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Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno+12 more
wiley +1 more source
Interplay of student characteristics multidimensional engagement and influencing factors in online computer science education. [PDF]
Zhang W+5 more
europepmc +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu+12 more
wiley +1 more source
CRISPR-CISH: an in situ chromogenic DNA repeat detection system for research and life science education. [PDF]
Potlapalli BP+4 more
europepmc +1 more source
Editorial : Basic Medical Science Education in Community Hospitals [PDF]
Carl F. Schmidt
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