Results 101 to 110 of about 10,899,612 (352)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

I International Congress of Science and Technology Morona Santiago CICTMS ESPOCH 2020

ESPOCH Congresses, 2021
Ing. Miguel Angel Osorio Rivera, MSc., General Coordinator of the I International Congress of Science, Technology Morona Santiago CICTMS ESPOCH   +3 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Teaching trust in science: a critical new focus for science education

Frontiers in Communication
The recent pandemic has revealed the importance of understanding how scientific knowledge is produced, if citizens are to make decisions that protect themselves, their communities, and their nations. Creating such an understanding presents a critical and
Karen Hopkin, Keith Roberts, Bruce Alberts   +2 more
doaj   +1 more source

Science in General Education [PDF]

The Journal of General Education, 2013
AbstractGeneral education must develop in students an appreciation of the power of science, how it works, why it is an effective knowledge generation tool, and what it can deliver. Knowing what science has discovered is desirable but less important.
openaire   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Scientific knowledge contributed by general science, biology, chemistry, and physics in relation to teachers' grades [PDF]

, 1940
George Tempel McKinney
openalex   +1 more source

From Wormholes to the Warp Drive: Using theoretical physics to place ultimate bounds on technology [PDF]

, 2002
The serious study of such science fiction staples as wormholes, time travel, and the warp drive, as a means of understanding and constraining possible realistic solutions within General Relativity is reviewed.Comment: 10 pages LaTeX; to appear in Phi ...
Hiscock, William A.
core   +1 more source

Discussion of "Calibrated Bayes, for Statistics in General, and Missing Data in Particular" by R. J. A. Little

, 2011
Discussion of "Calibrated Bayes, for Statistics in General, and Missing Data in Particular" by R. Little [arXiv:1108.1917]Comment: Published in at http://dx.doi.org/10.1214/10-STS318B the Statistical Science (http://www.imstat.org/sts/) by the ...
Larsen, Michael D.
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source