Results 151 to 160 of about 10,696,797 (331)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source
GENERAL PHYSIOLOGY. An Outline of the Science of Life
Max Verworn, Jelliffe
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias+12 more
wiley +1 more source
SOME TANGIBLE RESULTS FROM A COURSE IN GENERAL SCIENCE1 [PDF]
George Mounce
openalex +1 more source
Bringing Ocean Science News To the Classroom [PDF]
One of the goals of COSEE-Ocean Systems and its partners is to work toward bridging the gap between "school science" and "scientist science," in the context of using ocean examples to guide science inquiry.
core
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Defining medical basic science: general internists' special role in the reformation of medical school education. [PDF]
Jacobs EA, Kalet A.
europepmc +1 more source