Results 71 to 80 of about 20,984,995 (345)

Public knowledge about polar regions increases while concerns remain unchanged [PDF]

open access: yes, 2012
The authors of this brief conduct the first comparative analysis of the polar questions that were part of the National Opinion Research Center\u27s 2006 and 2010 General Social Survey.
Cutler, Matthew J.   +2 more
core   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Secondary social science teacher training in Papua New Guinea and secondary social studies teacher training in New Zealand : a comparative study : a thesis presented in partial fulfilment of the requirements for the degree of Masters in Education at Massey University [PDF]

open access: yes, 1982
This thesis is presented in a form of a report on a comparative documentary survey of secondary social science teacher training in Papua New Guinea and secondary social studies teacher training in New Zealand.
André, Elisabeth, Rist, Thomas
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

RWU Professor June Speakman Sworn into Rhode Island House of Representatives [PDF]

open access: yes, 2019
Roger Williams University Professor of Political Science June Speakman was sworn in to the Rhode Island House of Representatives by Attorney General Peter F.
Rubin, Julia
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

School of Ants goes to college: integrating citizen science into the general education classroom increases engagement with science

open access: yes, 2016
Citizen science has proven useful in advancing scientific research, but participant learning outcomes are not often assessed. This case study describes the implementation and tailoring of an in-depth assessment of the educational impact of two citizen ...
Tyler Vitone   +5 more
semanticscholar   +1 more source

Redesigning a General Education Science Course to Promote Critical Thinking

open access: yesCBE - Life Sciences Education, 2015
Traditional general education science courses appear ineffective at helping students improve their critical-thinking skills and engage with discomforting topics (e.g., evolution).
Matthew P. Rowe   +6 more
semanticscholar   +1 more source

Attitudes in Physics Education: An Alternative Approach to Teaching Physics to Non-Science College Students [PDF]

open access: yes, 2000
In this article, we present an alternative way of teaching conceptual physics for non-science majors by depicting the role of physics in today\u27s technology.
Brown, B. L.   +2 more
core   +1 more source

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